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Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide v...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608164/ https://www.ncbi.nlm.nih.gov/pubmed/37888482 http://dx.doi.org/10.3390/md21100547 |
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author | Wang, Wei Gu, Liting Wang, Jiahao Hu, Xubin Wei, Bin Zhang, Huawei Wang, Hong Chen, Jianwei |
author_facet | Wang, Wei Gu, Liting Wang, Jiahao Hu, Xubin Wei, Bin Zhang, Huawei Wang, Hong Chen, Jianwei |
author_sort | Wang, Wei |
collection | PubMed |
description | In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides—according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds. |
format | Online Article Text |
id | pubmed-10608164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106081642023-10-28 Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms Wang, Wei Gu, Liting Wang, Jiahao Hu, Xubin Wei, Bin Zhang, Huawei Wang, Hong Chen, Jianwei Mar Drugs Review In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides—according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds. MDPI 2023-10-22 /pmc/articles/PMC10608164/ /pubmed/37888482 http://dx.doi.org/10.3390/md21100547 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Wei Gu, Liting Wang, Jiahao Hu, Xubin Wei, Bin Zhang, Huawei Wang, Hong Chen, Jianwei Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title_full | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title_fullStr | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title_full_unstemmed | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title_short | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
title_sort | recent advances in polypeptide antibiotics derived from marine microorganisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608164/ https://www.ncbi.nlm.nih.gov/pubmed/37888482 http://dx.doi.org/10.3390/md21100547 |
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