Cargando…
The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients
Background and Objectives: Chronic kidney disease (CKD) is a global public health issue with rising incidence linked to substantial morbidity and mortality. Selenium, an antioxidant trace element, has been linked to low serum levels in end-stage renal disease. Restless Leg Syndrome (RLS), a sleep di...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608171/ https://www.ncbi.nlm.nih.gov/pubmed/37893513 http://dx.doi.org/10.3390/medicina59101795 |
_version_ | 1785127717429051392 |
---|---|
author | Tutan, Duygu Ulfberg, Jan Aydemir, Nihal Eser, Barış Doğan, İbrahim |
author_facet | Tutan, Duygu Ulfberg, Jan Aydemir, Nihal Eser, Barış Doğan, İbrahim |
author_sort | Tutan, Duygu |
collection | PubMed |
description | Background and Objectives: Chronic kidney disease (CKD) is a global public health issue with rising incidence linked to substantial morbidity and mortality. Selenium, an antioxidant trace element, has been linked to low serum levels in end-stage renal disease. Restless Leg Syndrome (RLS), a sleep disorder, is prevalent in CKD patients and significantly impacts their quality of life. The objective of this study was to examine the correlation between serum selenium levels and the prevalence of restless leg syndrome in individuals with chronic kidney disease. Materials and Methods: Forty-six CKD patients undergoing serum selenium level assessments between 1 January 2020 and 28 February 2022, at the Hitit University Faculty of Medicine Department of Nephrology Outpatient Clinic or Hemodialysis Unit, were included. Patients over 18 years of age with no history of hematological or oncological diseases or acute or chronic inflammatory conditions were included in the study groups. Patients taking selenium supplements were excluded. Demographic data, comorbidities, and laboratory values were collected, and RLS presence and severity were evaluated. Statistical analyses include descriptive statistics, correlation analysis, the Mann–Whitney U test, Student’s t test, and Chi-square test. Results: Among the 46 patients, 16 (34.78%) had RLS symptoms. The patient group included 34.78% predialysis, 34.78% peritoneal dialysis, and 30.44% hemodialysis patients, with a median age of 47.98 years. There was no difference in age, gender, and Charlson comorbidity between patients with or without RLS (p = 0.881, p = 0.702, p = 0.650). RLS prevalence varied across CKD subgroups, with hemodialysis patients having a higher prevalence (p = 0.036). Clinical parameters such as blood urea nitrogen, creatinine, calcium, phosphorus, platelet counts, and parathyroid hormone levels exhibited significant differences between patients with and without RLS (p < 0.05). Serum selenium levels were not significantly different between patients with and without RLS (p = 0.327). Conclusions: With an increased comorbidity burden, CKD poses a significant healthcare challenge. When accompanied by RLS, this burden can be debilitating. The difference in CKD stages between groups has shed light on a critical determinant of RLS in this population, emphasizing the role of the chronic kidney disease stage. In our study, serum selenium levels were not associated with the presence and severity of RLS. However, prospective studies with larger numbers of participants are needed to draw a definitive conclusion. |
format | Online Article Text |
id | pubmed-10608171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106081712023-10-28 The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients Tutan, Duygu Ulfberg, Jan Aydemir, Nihal Eser, Barış Doğan, İbrahim Medicina (Kaunas) Article Background and Objectives: Chronic kidney disease (CKD) is a global public health issue with rising incidence linked to substantial morbidity and mortality. Selenium, an antioxidant trace element, has been linked to low serum levels in end-stage renal disease. Restless Leg Syndrome (RLS), a sleep disorder, is prevalent in CKD patients and significantly impacts their quality of life. The objective of this study was to examine the correlation between serum selenium levels and the prevalence of restless leg syndrome in individuals with chronic kidney disease. Materials and Methods: Forty-six CKD patients undergoing serum selenium level assessments between 1 January 2020 and 28 February 2022, at the Hitit University Faculty of Medicine Department of Nephrology Outpatient Clinic or Hemodialysis Unit, were included. Patients over 18 years of age with no history of hematological or oncological diseases or acute or chronic inflammatory conditions were included in the study groups. Patients taking selenium supplements were excluded. Demographic data, comorbidities, and laboratory values were collected, and RLS presence and severity were evaluated. Statistical analyses include descriptive statistics, correlation analysis, the Mann–Whitney U test, Student’s t test, and Chi-square test. Results: Among the 46 patients, 16 (34.78%) had RLS symptoms. The patient group included 34.78% predialysis, 34.78% peritoneal dialysis, and 30.44% hemodialysis patients, with a median age of 47.98 years. There was no difference in age, gender, and Charlson comorbidity between patients with or without RLS (p = 0.881, p = 0.702, p = 0.650). RLS prevalence varied across CKD subgroups, with hemodialysis patients having a higher prevalence (p = 0.036). Clinical parameters such as blood urea nitrogen, creatinine, calcium, phosphorus, platelet counts, and parathyroid hormone levels exhibited significant differences between patients with and without RLS (p < 0.05). Serum selenium levels were not significantly different between patients with and without RLS (p = 0.327). Conclusions: With an increased comorbidity burden, CKD poses a significant healthcare challenge. When accompanied by RLS, this burden can be debilitating. The difference in CKD stages between groups has shed light on a critical determinant of RLS in this population, emphasizing the role of the chronic kidney disease stage. In our study, serum selenium levels were not associated with the presence and severity of RLS. However, prospective studies with larger numbers of participants are needed to draw a definitive conclusion. MDPI 2023-10-09 /pmc/articles/PMC10608171/ /pubmed/37893513 http://dx.doi.org/10.3390/medicina59101795 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tutan, Duygu Ulfberg, Jan Aydemir, Nihal Eser, Barış Doğan, İbrahim The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title | The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title_full | The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title_fullStr | The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title_full_unstemmed | The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title_short | The Relationship between Serum Selenium Levels and Restless Leg Syndrome in Chronic Kidney Disease Patients |
title_sort | relationship between serum selenium levels and restless leg syndrome in chronic kidney disease patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608171/ https://www.ncbi.nlm.nih.gov/pubmed/37893513 http://dx.doi.org/10.3390/medicina59101795 |
work_keys_str_mv | AT tutanduygu therelationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT ulfbergjan therelationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT aydemirnihal therelationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT eserbarıs therelationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT doganibrahim therelationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT tutanduygu relationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT ulfbergjan relationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT aydemirnihal relationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT eserbarıs relationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients AT doganibrahim relationshipbetweenserumseleniumlevelsandrestlesslegsyndromeinchronickidneydiseasepatients |