Cargando…
Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats
The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608188/ https://www.ncbi.nlm.nih.gov/pubmed/37888441 http://dx.doi.org/10.3390/md21100506 |
_version_ | 1785127721483894784 |
---|---|
author | Carolo, Anna Melotti, Luca Zivelonghi, Giulia Sacchetto, Roberta Akyürek, Eylem Emek Martinello, Tiziana Venerando, Andrea Iacopetti, Ilaria Sugni, Michela Martinelli, Giordana Roncoroni, Margherita Marzorati, Stefania Barbon, Silvia Contran, Martina Incendi, Damiana Perozzo, Filippo Porzionato, Andrea Vindigni, Vincenzo Patruno, Marco |
author_facet | Carolo, Anna Melotti, Luca Zivelonghi, Giulia Sacchetto, Roberta Akyürek, Eylem Emek Martinello, Tiziana Venerando, Andrea Iacopetti, Ilaria Sugni, Michela Martinelli, Giordana Roncoroni, Margherita Marzorati, Stefania Barbon, Silvia Contran, Martina Incendi, Damiana Perozzo, Filippo Porzionato, Andrea Vindigni, Vincenzo Patruno, Marco |
author_sort | Carolo, Anna |
collection | PubMed |
description | The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal substitutes have been used to cover the lesion to facilitate cell proliferation, although very little is known about the application of novel matrix obtained from marine collagen. From food waste we isolated eco-friendly collagen, naturally enriched with glycosaminoglycans, to produce an innovative marine-derived biomaterial assembled as a novel bi-layered skin substitute (Marine Collagen Dermal Template or MCDT). The present work carried out a preliminary experimental in vivo comparative analysis between the MCDT and Integra, one of the most widely used dermal templates for wound management, in a rat model of full-thickness skin wounds. Clinical, histological, and molecular evaluations showed that the MCDT might be a valuable tool in promoting and supporting skin wound healing: it is biocompatible, as no adverse reactions were observed, along with stimulating angiogenesis and the deposition of mature collagen. Therefore, the two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT. |
format | Online Article Text |
id | pubmed-10608188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106081882023-10-28 Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats Carolo, Anna Melotti, Luca Zivelonghi, Giulia Sacchetto, Roberta Akyürek, Eylem Emek Martinello, Tiziana Venerando, Andrea Iacopetti, Ilaria Sugni, Michela Martinelli, Giordana Roncoroni, Margherita Marzorati, Stefania Barbon, Silvia Contran, Martina Incendi, Damiana Perozzo, Filippo Porzionato, Andrea Vindigni, Vincenzo Patruno, Marco Mar Drugs Article The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal substitutes have been used to cover the lesion to facilitate cell proliferation, although very little is known about the application of novel matrix obtained from marine collagen. From food waste we isolated eco-friendly collagen, naturally enriched with glycosaminoglycans, to produce an innovative marine-derived biomaterial assembled as a novel bi-layered skin substitute (Marine Collagen Dermal Template or MCDT). The present work carried out a preliminary experimental in vivo comparative analysis between the MCDT and Integra, one of the most widely used dermal templates for wound management, in a rat model of full-thickness skin wounds. Clinical, histological, and molecular evaluations showed that the MCDT might be a valuable tool in promoting and supporting skin wound healing: it is biocompatible, as no adverse reactions were observed, along with stimulating angiogenesis and the deposition of mature collagen. Therefore, the two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT. MDPI 2023-09-26 /pmc/articles/PMC10608188/ /pubmed/37888441 http://dx.doi.org/10.3390/md21100506 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carolo, Anna Melotti, Luca Zivelonghi, Giulia Sacchetto, Roberta Akyürek, Eylem Emek Martinello, Tiziana Venerando, Andrea Iacopetti, Ilaria Sugni, Michela Martinelli, Giordana Roncoroni, Margherita Marzorati, Stefania Barbon, Silvia Contran, Martina Incendi, Damiana Perozzo, Filippo Porzionato, Andrea Vindigni, Vincenzo Patruno, Marco Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title | Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title_full | Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title_fullStr | Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title_full_unstemmed | Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title_short | Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats |
title_sort | mutable collagenous tissue isolated from echinoderms leads to the production of a dermal template that is biocompatible and effective for wound healing in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608188/ https://www.ncbi.nlm.nih.gov/pubmed/37888441 http://dx.doi.org/10.3390/md21100506 |
work_keys_str_mv | AT caroloanna mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT melottiluca mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT zivelonghigiulia mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT sacchettoroberta mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT akyurekeylememek mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT martinellotiziana mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT venerandoandrea mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT iacopettiilaria mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT sugnimichela mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT martinelligiordana mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT roncoronimargherita mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT marzoratistefania mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT barbonsilvia mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT contranmartina mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT incendidamiana mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT perozzofilippo mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT porzionatoandrea mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT vindignivincenzo mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats AT patrunomarco mutablecollagenoustissueisolatedfromechinodermsleadstotheproductionofadermaltemplatethatisbiocompatibleandeffectiveforwoundhealinginrats |