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Therapeutic Potential of Myrtenal and Its Derivatives—A Review

The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability to exhibit a wide range in biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vas...

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Autores principales: Dragomanova, Stela, Andonova, Velichka, Volcho, Konstantin, Salakhutdinov, Nariman, Kalfin, Reni, Tancheva, Lyubka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608190/
https://www.ncbi.nlm.nih.gov/pubmed/37895468
http://dx.doi.org/10.3390/life13102086
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author Dragomanova, Stela
Andonova, Velichka
Volcho, Konstantin
Salakhutdinov, Nariman
Kalfin, Reni
Tancheva, Lyubka
author_facet Dragomanova, Stela
Andonova, Velichka
Volcho, Konstantin
Salakhutdinov, Nariman
Kalfin, Reni
Tancheva, Lyubka
author_sort Dragomanova, Stela
collection PubMed
description The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability to exhibit a wide range in biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vasodilating properties. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing effects in experimental dementia and Parkinson’s disease. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive avenue within experimental pharmacology, offering a promising approach for the therapy of diverse pathological conditions. Biologically active substances such as monoterpenes, for example, borneol, camphor, geraniol, pinene, and thymol, are used to synthesize compounds with analgesic, anti-inflammatory, anticonvulsive, antidepressant, anti-Alzheimer’s, antiparkinsonian, antiviral and antibacterial (antituberculosis) properties. Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, the conjugation of myrtenal with the established pharmacophore adamantane enables the augmentation of several of its pivotal properties. Myrtenal–adamantane derivatives exhibited a variety of beneficial characteristics, such as antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective properties, which are worth examining in more detail and at length.
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spelling pubmed-106081902023-10-28 Therapeutic Potential of Myrtenal and Its Derivatives—A Review Dragomanova, Stela Andonova, Velichka Volcho, Konstantin Salakhutdinov, Nariman Kalfin, Reni Tancheva, Lyubka Life (Basel) Review The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability to exhibit a wide range in biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vasodilating properties. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing effects in experimental dementia and Parkinson’s disease. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive avenue within experimental pharmacology, offering a promising approach for the therapy of diverse pathological conditions. Biologically active substances such as monoterpenes, for example, borneol, camphor, geraniol, pinene, and thymol, are used to synthesize compounds with analgesic, anti-inflammatory, anticonvulsive, antidepressant, anti-Alzheimer’s, antiparkinsonian, antiviral and antibacterial (antituberculosis) properties. Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, the conjugation of myrtenal with the established pharmacophore adamantane enables the augmentation of several of its pivotal properties. Myrtenal–adamantane derivatives exhibited a variety of beneficial characteristics, such as antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective properties, which are worth examining in more detail and at length. MDPI 2023-10-20 /pmc/articles/PMC10608190/ /pubmed/37895468 http://dx.doi.org/10.3390/life13102086 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dragomanova, Stela
Andonova, Velichka
Volcho, Konstantin
Salakhutdinov, Nariman
Kalfin, Reni
Tancheva, Lyubka
Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title_full Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title_fullStr Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title_full_unstemmed Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title_short Therapeutic Potential of Myrtenal and Its Derivatives—A Review
title_sort therapeutic potential of myrtenal and its derivatives—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608190/
https://www.ncbi.nlm.nih.gov/pubmed/37895468
http://dx.doi.org/10.3390/life13102086
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