Cargando…

Intra-Cranial Arterial Calcifications in Hemodialysis Patients

Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The...

Descripción completa

Detalles Bibliográficos
Autores principales: Fanadka, Feda, Rozenberg, Ilan, Nacasch, Naomi, Einbinder, Yael, Benchetrit, Sydney, Wand, Ori, Hod, Tammy, Cohen-Hagai, Keren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608215/
https://www.ncbi.nlm.nih.gov/pubmed/37893424
http://dx.doi.org/10.3390/medicina59101706
_version_ 1785127727774302208
author Fanadka, Feda
Rozenberg, Ilan
Nacasch, Naomi
Einbinder, Yael
Benchetrit, Sydney
Wand, Ori
Hod, Tammy
Cohen-Hagai, Keren
author_facet Fanadka, Feda
Rozenberg, Ilan
Nacasch, Naomi
Einbinder, Yael
Benchetrit, Sydney
Wand, Ori
Hod, Tammy
Cohen-Hagai, Keren
author_sort Fanadka, Feda
collection PubMed
description Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The aim of this retrospective study was to assess the predictors and outcomes of ICAC in MHD patients compared to a control group without kidney disease. A blinded neuroradiologist graded ICAC in brain imaging (computerized tomography) of MHD patients. Age- and sex-matched patients with normal kidney function served as the control group. Results: A total of 280 patients were included in the cohort; 140 of them were MHD patients with a mean ICAC score of 2.3 ± 0.2 versus a mean ICAC score of 1.4 ± 0.2 in the control group (p < 0.01). More than 90% of hemodialysis patients in our study had some degree of ICAC. Lower albumin and higher phosphorus and CRP levels were associated with increased ICACs. The multivariate analysis model for predictors of 1-year mortality demonstrated an increased odds ratio for mortality as the ICAC score increased. Conclusions: ICAC is very prevalent among MHD patients and results not simply from passive deposition of calcium and phosphate but rather from complex and active processes involving inflammation and structural changes in blood vessels. ICAC independently predicted all-cause mortality and may help with risk stratification of this high-risk population.
format Online
Article
Text
id pubmed-10608215
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106082152023-10-28 Intra-Cranial Arterial Calcifications in Hemodialysis Patients Fanadka, Feda Rozenberg, Ilan Nacasch, Naomi Einbinder, Yael Benchetrit, Sydney Wand, Ori Hod, Tammy Cohen-Hagai, Keren Medicina (Kaunas) Article Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The aim of this retrospective study was to assess the predictors and outcomes of ICAC in MHD patients compared to a control group without kidney disease. A blinded neuroradiologist graded ICAC in brain imaging (computerized tomography) of MHD patients. Age- and sex-matched patients with normal kidney function served as the control group. Results: A total of 280 patients were included in the cohort; 140 of them were MHD patients with a mean ICAC score of 2.3 ± 0.2 versus a mean ICAC score of 1.4 ± 0.2 in the control group (p < 0.01). More than 90% of hemodialysis patients in our study had some degree of ICAC. Lower albumin and higher phosphorus and CRP levels were associated with increased ICACs. The multivariate analysis model for predictors of 1-year mortality demonstrated an increased odds ratio for mortality as the ICAC score increased. Conclusions: ICAC is very prevalent among MHD patients and results not simply from passive deposition of calcium and phosphate but rather from complex and active processes involving inflammation and structural changes in blood vessels. ICAC independently predicted all-cause mortality and may help with risk stratification of this high-risk population. MDPI 2023-09-24 /pmc/articles/PMC10608215/ /pubmed/37893424 http://dx.doi.org/10.3390/medicina59101706 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fanadka, Feda
Rozenberg, Ilan
Nacasch, Naomi
Einbinder, Yael
Benchetrit, Sydney
Wand, Ori
Hod, Tammy
Cohen-Hagai, Keren
Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title_full Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title_fullStr Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title_full_unstemmed Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title_short Intra-Cranial Arterial Calcifications in Hemodialysis Patients
title_sort intra-cranial arterial calcifications in hemodialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608215/
https://www.ncbi.nlm.nih.gov/pubmed/37893424
http://dx.doi.org/10.3390/medicina59101706
work_keys_str_mv AT fanadkafeda intracranialarterialcalcificationsinhemodialysispatients
AT rozenbergilan intracranialarterialcalcificationsinhemodialysispatients
AT nacaschnaomi intracranialarterialcalcificationsinhemodialysispatients
AT einbinderyael intracranialarterialcalcificationsinhemodialysispatients
AT benchetritsydney intracranialarterialcalcificationsinhemodialysispatients
AT wandori intracranialarterialcalcificationsinhemodialysispatients
AT hodtammy intracranialarterialcalcificationsinhemodialysispatients
AT cohenhagaikeren intracranialarterialcalcificationsinhemodialysispatients