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Intra-Cranial Arterial Calcifications in Hemodialysis Patients
Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608215/ https://www.ncbi.nlm.nih.gov/pubmed/37893424 http://dx.doi.org/10.3390/medicina59101706 |
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author | Fanadka, Feda Rozenberg, Ilan Nacasch, Naomi Einbinder, Yael Benchetrit, Sydney Wand, Ori Hod, Tammy Cohen-Hagai, Keren |
author_facet | Fanadka, Feda Rozenberg, Ilan Nacasch, Naomi Einbinder, Yael Benchetrit, Sydney Wand, Ori Hod, Tammy Cohen-Hagai, Keren |
author_sort | Fanadka, Feda |
collection | PubMed |
description | Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The aim of this retrospective study was to assess the predictors and outcomes of ICAC in MHD patients compared to a control group without kidney disease. A blinded neuroradiologist graded ICAC in brain imaging (computerized tomography) of MHD patients. Age- and sex-matched patients with normal kidney function served as the control group. Results: A total of 280 patients were included in the cohort; 140 of them were MHD patients with a mean ICAC score of 2.3 ± 0.2 versus a mean ICAC score of 1.4 ± 0.2 in the control group (p < 0.01). More than 90% of hemodialysis patients in our study had some degree of ICAC. Lower albumin and higher phosphorus and CRP levels were associated with increased ICACs. The multivariate analysis model for predictors of 1-year mortality demonstrated an increased odds ratio for mortality as the ICAC score increased. Conclusions: ICAC is very prevalent among MHD patients and results not simply from passive deposition of calcium and phosphate but rather from complex and active processes involving inflammation and structural changes in blood vessels. ICAC independently predicted all-cause mortality and may help with risk stratification of this high-risk population. |
format | Online Article Text |
id | pubmed-10608215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106082152023-10-28 Intra-Cranial Arterial Calcifications in Hemodialysis Patients Fanadka, Feda Rozenberg, Ilan Nacasch, Naomi Einbinder, Yael Benchetrit, Sydney Wand, Ori Hod, Tammy Cohen-Hagai, Keren Medicina (Kaunas) Article Background and objectives: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. Materials and Methods: The aim of this retrospective study was to assess the predictors and outcomes of ICAC in MHD patients compared to a control group without kidney disease. A blinded neuroradiologist graded ICAC in brain imaging (computerized tomography) of MHD patients. Age- and sex-matched patients with normal kidney function served as the control group. Results: A total of 280 patients were included in the cohort; 140 of them were MHD patients with a mean ICAC score of 2.3 ± 0.2 versus a mean ICAC score of 1.4 ± 0.2 in the control group (p < 0.01). More than 90% of hemodialysis patients in our study had some degree of ICAC. Lower albumin and higher phosphorus and CRP levels were associated with increased ICACs. The multivariate analysis model for predictors of 1-year mortality demonstrated an increased odds ratio for mortality as the ICAC score increased. Conclusions: ICAC is very prevalent among MHD patients and results not simply from passive deposition of calcium and phosphate but rather from complex and active processes involving inflammation and structural changes in blood vessels. ICAC independently predicted all-cause mortality and may help with risk stratification of this high-risk population. MDPI 2023-09-24 /pmc/articles/PMC10608215/ /pubmed/37893424 http://dx.doi.org/10.3390/medicina59101706 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fanadka, Feda Rozenberg, Ilan Nacasch, Naomi Einbinder, Yael Benchetrit, Sydney Wand, Ori Hod, Tammy Cohen-Hagai, Keren Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title | Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title_full | Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title_fullStr | Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title_full_unstemmed | Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title_short | Intra-Cranial Arterial Calcifications in Hemodialysis Patients |
title_sort | intra-cranial arterial calcifications in hemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608215/ https://www.ncbi.nlm.nih.gov/pubmed/37893424 http://dx.doi.org/10.3390/medicina59101706 |
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