Multicopy Chromosome Integration and Deletion of Negative Global Regulators Significantly Increased the Heterologous Production of Aborycin in Streptomyces coelicolor

Aborycin is a type I lasso peptide with a stable interlocked structure, offering a favorable framework for drug development. The aborycin biosynthetic gene cluster gul from marine sponge-associated Streptomyces sp. HNS054 was cloned and integrated into the chromosome of S. coelicolor hosts with diff...

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Detalles Bibliográficos
Autores principales: Li, Jia-Yi, Liang, Jun-Yu, Liu, Zhao-Yuan, Yi, Yue-Zhao, Zhao, Jing, Huang, Zhi-Yong, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608281/
https://www.ncbi.nlm.nih.gov/pubmed/37888469
http://dx.doi.org/10.3390/md21100534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608281/
https://www.ncbi.nlm.nih.gov/pubmed/37888469
http://dx.doi.org/10.3390/md21100534

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