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Investigations of Single-Subunit tRNA Methyltransferases from Yeast

tRNA methylations, including base modification and 2’-O-methylation of ribose moiety, play critical roles in the structural stabilization of tRNAs and the fidelity and efficiency of protein translation. These modifications are catalyzed by tRNA methyltransferases (TRMs). Some of the TRMs from yeast...

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Autores principales: Wang, Zhongyuan, Xu, Xiangbin, Li, Xinhai, Fang, Jiaqi, Huang, Zhenkuai, Zhang, Mengli, Liu, Jiameng, Qiu, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608323/
https://www.ncbi.nlm.nih.gov/pubmed/37888286
http://dx.doi.org/10.3390/jof9101030
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author Wang, Zhongyuan
Xu, Xiangbin
Li, Xinhai
Fang, Jiaqi
Huang, Zhenkuai
Zhang, Mengli
Liu, Jiameng
Qiu, Xiaoting
author_facet Wang, Zhongyuan
Xu, Xiangbin
Li, Xinhai
Fang, Jiaqi
Huang, Zhenkuai
Zhang, Mengli
Liu, Jiameng
Qiu, Xiaoting
author_sort Wang, Zhongyuan
collection PubMed
description tRNA methylations, including base modification and 2’-O-methylation of ribose moiety, play critical roles in the structural stabilization of tRNAs and the fidelity and efficiency of protein translation. These modifications are catalyzed by tRNA methyltransferases (TRMs). Some of the TRMs from yeast can fully function only by a single subunit. In this study, after performing the primary bioinformatic analyses, the progress of the studies of yeast single-subunit TRMs, as well as the studies of their homologues from yeast and other types of eukaryotes and the corresponding TRMs from other types of organisms was systematically reviewed, which will facilitate the understanding of the evolutionary origin of functional diversity of eukaryotic single-subunit TRM.
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spelling pubmed-106083232023-10-28 Investigations of Single-Subunit tRNA Methyltransferases from Yeast Wang, Zhongyuan Xu, Xiangbin Li, Xinhai Fang, Jiaqi Huang, Zhenkuai Zhang, Mengli Liu, Jiameng Qiu, Xiaoting J Fungi (Basel) Review tRNA methylations, including base modification and 2’-O-methylation of ribose moiety, play critical roles in the structural stabilization of tRNAs and the fidelity and efficiency of protein translation. These modifications are catalyzed by tRNA methyltransferases (TRMs). Some of the TRMs from yeast can fully function only by a single subunit. In this study, after performing the primary bioinformatic analyses, the progress of the studies of yeast single-subunit TRMs, as well as the studies of their homologues from yeast and other types of eukaryotes and the corresponding TRMs from other types of organisms was systematically reviewed, which will facilitate the understanding of the evolutionary origin of functional diversity of eukaryotic single-subunit TRM. MDPI 2023-10-19 /pmc/articles/PMC10608323/ /pubmed/37888286 http://dx.doi.org/10.3390/jof9101030 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Zhongyuan
Xu, Xiangbin
Li, Xinhai
Fang, Jiaqi
Huang, Zhenkuai
Zhang, Mengli
Liu, Jiameng
Qiu, Xiaoting
Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title_full Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title_fullStr Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title_full_unstemmed Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title_short Investigations of Single-Subunit tRNA Methyltransferases from Yeast
title_sort investigations of single-subunit trna methyltransferases from yeast
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608323/
https://www.ncbi.nlm.nih.gov/pubmed/37888286
http://dx.doi.org/10.3390/jof9101030
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