Cargando…

Efficacy and Safety of Setmelanotide, a Melanocortin-4 Receptor Agonist, for Obese Patients: A Systematic Review and Meta-Analysis

Background: A malfunction in the melanocortin-4 receptor (MC4R) is associated with obesity in rare genetic syndromes; setmelanotide is a new drug that activates this receptor and is being used to treat severe obesity. This meta-analysis evaluated the efficacy and safety of setmelanotide for weight l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferraz Barbosa, Bárbara, Aquino de Moraes, Francisco Cezar, Bordignon Barbosa, Camila, Palavicini Santos, Plínio Takashi Karubi, Pereira da Silva, Izael, Araujo Alves da Silva, Bruno, Cristine Marques Barros, Jamile, Rodríguez Burbano, Rommel Mario, Pereira Carneiro dos Santos, Ney, Rodrigues Fernandes, Marianne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Systematic Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608339/ https://www.ncbi.nlm.nih.gov/pubmed/37888071 http://dx.doi.org/10.3390/jpm13101460

Ejemplares similares

Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome
por: Haws, Robert, et al.
Publicado: (2020)

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
por: Collet, Tinh-Hai, et al.
Publicado: (2017)

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
por: Heyder, Nicolas A., et al.
Publicado: (2021)

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype
por: Kamermans, Alwin, et al.
Publicado: (2019)

A Phase 3 Trial in Participants With Obesity Due to Bardet-Biedl Syndrome or Alström Syndrome: Efficacy and Safety of the Melanocortin 4 Receptor Agonist Setmelanotide
por: Haws, Robert, et al.
Publicado: (2021)

Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon
por: da Silva Menezes, Elisa, et al.
Publicado: (2023)

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review
por: de Moraes, Francisco Cezar Aquino, et al.
Publicado: (2023)

Analysis of Increased EGFR and IGF-1R Signaling and Its Correlation with Socio-Epidemiological Features and Biological Profile in Breast Cancer Patients: A Study in Northern Brazil
por: Silva Rocha, Francianne, et al.
Publicado: (2021)

Breast Cancer: Clinical–Epidemiological Profile and Toxicities of Women Receiving Treatment with Taxanes in the Amazon Region
por: Costa, Marta Solange Camarinha Ramos, et al.
Publicado: (2023)

Correlation between Genomic Variants and Worldwide Epidemiology of Prostate Cancer
por: Vieira, Giovana Miranda, et al.
Publicado: (2022)

Computational Identification and Characterization of New microRNAs in Human Platelets Stored in a Blood Bank
por: Maués, Jersey Heitor da Silva, et al.
Publicado: (2020)

MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks—A Review
por: Maués, Jersey Heitor da Silva, et al.
Publicado: (2019)

ODP606 Long-term Efficacy of Setmelanotide in Patients With Bardet-Biedl Syndrome
por: Argente, Jesús, et al.
Publicado: (2022)

Setmelanotide: a promising advancement for pediatric patients with rare forms of genetic obesity
por: Trapp, Christine M., et al.
Publicado: (2023)

Melanocortins, Melanocortin Receptors and Multiple Sclerosis
por: Lisak, Robert P., et al.
Publicado: (2017)

Investigation of Genetic Factors and Clinical Data in Breast Cancer Highlights the Importance of Breastfeeding and Cancer History
por: Mercês, Amanda, et al.
Publicado: (2023)

The recurrence of odontogenic keratocysts in pediatric patients is associated with clinical findings of Gorlin-Goltz Syndrome
por: da Silva, Leorik Pereira, et al.
Publicado: (2020)

Polymorphisms of ADME-related genes and their implications for drug safety and efficacy in Amazonian Amerindians
por: Rodrigues, Juliana Carla Gomes, et al.
Publicado: (2019)

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide
por: Wabitsch, Martin, et al.
Publicado: (2022)

ODP607 Long-term Efficacy of Setmelanotide in Patients With POMC or LEPR Deficiency Obesity
por: Clément, Karine, et al.
Publicado: (2022)

FRI082 Impact Of Setmelanotide On Metabolic Parameters And Vital Signs In Patients With Hypothalamic Obesity
por: Jennifer Abuzzahab, M, et al.
Publicado: (2023)

Prevalence of burnout syndrome and associated factors in university professors working in Salvador, state of Bahia
por: Silva, Laís Peres, et al.
Publicado: (2021)

The impact of the COVID-19 pandemic in an intensive care unit (ICU): Psychiatric symptoms in healthcare professionals
por: da Silva, Flaviane Cristine Troglio, et al.
Publicado: (2021)

Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review
por: Santos, Renata Emmanuele Assunção, et al.
Publicado: (2021)

Understanding the Patient Experience of Hunger and Improved Quality of Life with Setmelanotide Treatment in POMC and LEPR Deficiencies
por: Wabitsch, Martin, et al.
Publicado: (2022)

Beneficial Effects of Setmelanotide in a 5-Year-Old Boy With POMC Deficiency and on His Caregivers
por: Dubern, Beatrice, et al.
Publicado: (2023)

SAT656 Weight Reduction After 6 Months Of Setmelanotide Treatment In Patients With Hypothalamic Obesity
por: Roth, Christian L, et al.
Publicado: (2023)

Timing of Onset of Adverse Events With Setmelanotide, an MC4R Agonist, in Patients With Severe Obesity Due to LEPR or POMC Deficiency
por: Clément, Karine, et al.
Publicado: (2021)

PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer: a systematic review and meta-analysis of randomized clinical trials
por: de Moraes, Francisco Cezar Aquino, et al.
Publicado: (2023)

Detection of Sepsis in Platelets Using MicroRNAs and Membrane Antigens
por: Vieira Corrêa, Priscilla Cristina Moura, et al.
Publicado: (2021)

Nutrition, Pharmacological and Training Strategies Adopted by Six Bodybuilders: Case Report and Critical Review
por: Gentil, Paulo, et al.
Publicado: (2017)

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease
por: Moscowitz, Anna Elizabeth, et al.
Publicado: (2019)

MicroRNA 320a and Membrane Antigens as Tools to Evaluate the Pathophysiology of Platelets Stored in Blood Banks
por: Vieira, Priscilla Cristina Moura, et al.
Publicado: (2022)

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon
por: Fernandes, Marianne Rodrigues, et al.
Publicado: (2021)

Association between SNPs in microRNAs and microRNAs-Machinery Genes with Susceptibility of Leprosy in the Amazon Population
por: da Silva, Mayara Natália Santana, et al.
Publicado: (2022)

Behavior and thermal comfort of light and dark coat dairy cows in the Eastern Amazon
por: da Silva, Welligton Conceição, et al.
Publicado: (2022)

Patient safety and the value of pharmaceutical intervention in a cancer hospital
por: Aguiar, Karina da Silva, et al.
Publicado: (2018)

Next Generation Antiobesity Medications: Setmelanotide, Semaglutide, Tirzepatide and Bimagrumab: What do They Mean for Clinical Practice?
por: Ryan, Donna H.
Publicado: (2021)

The efficacy and safety of setmelanotide in individuals with Bardet-Biedl syndrome or Alström syndrome: Phase 3 trial design
por: Haws, Robert M., et al.
Publicado: (2021)

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
por: Reininghaus, Nanina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6k1bm748o5i4sjgtgh0vdsvkce