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The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses

Background and Objectives: Coronary angiography is the gold standard for diagnosing coronary artery disease (CAD). In the case of borderline changes, patients require further diagnosis through ischemia assessment via one of the recommended methods of invasive evaluation. This study aimed to assess w...

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Autores principales: Zasada, Wojciech, Zdzierak, Barbara, Rakowski, Tomasz, Bobrowska, Beata, Krawczyk-Ożóg, Agata, Surowiec, Sławomir, Bartuś, Stanisław, Surdacki, Andrzej, Dziewierz, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608417/
https://www.ncbi.nlm.nih.gov/pubmed/37893581
http://dx.doi.org/10.3390/medicina59101863
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author Zasada, Wojciech
Zdzierak, Barbara
Rakowski, Tomasz
Bobrowska, Beata
Krawczyk-Ożóg, Agata
Surowiec, Sławomir
Bartuś, Stanisław
Surdacki, Andrzej
Dziewierz, Artur
author_facet Zasada, Wojciech
Zdzierak, Barbara
Rakowski, Tomasz
Bobrowska, Beata
Krawczyk-Ożóg, Agata
Surowiec, Sławomir
Bartuś, Stanisław
Surdacki, Andrzej
Dziewierz, Artur
author_sort Zasada, Wojciech
collection PubMed
description Background and Objectives: Coronary angiography is the gold standard for diagnosing coronary artery disease (CAD). In the case of borderline changes, patients require further diagnosis through ischemia assessment via one of the recommended methods of invasive evaluation. This study aimed to assess whether clinical factors influence the risk of a positive result in invasive myocardial ischemia assessment and if these potential factors change with the patient’s age and the consistency of ischemia assessment. Materials and Methods: Data were collected retrospectively on all consecutive patients hospitalized in the University Hospital in Krakow between 2020 and 2021, on whom physiological assessments of coronary circulation were performed. Patients were divided into two groups: patients aged 60 or younger and patients older than 60. Results: Despite the older patients having more risk factors for CAD, their physiological assessment results of borderline lesions were similar to those of the younger patients. Positive fractional flow reserve (FFR) assessments were obtained from almost 50% of vessels. In the younger patients, cigarette use and type 2 diabetes mellitus increased the risk of a positive FFR result by 3.5 and 2.5 times, respectively. In the older patients, male gender and peripheral vascular disease significantly increased the risk of a positive FFR by 2.5 and 2 times, respectively. Conclusions: Clinical characteristics of patients undergoing physiological assessment of borderline coronary stenosis varied significantly by age. Refining the definition of borderline lesions to include age, gender, and other factors may improve the identification of patients who would benefit from physiological assessment and coronary revascularization.
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spelling pubmed-106084172023-10-28 The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses Zasada, Wojciech Zdzierak, Barbara Rakowski, Tomasz Bobrowska, Beata Krawczyk-Ożóg, Agata Surowiec, Sławomir Bartuś, Stanisław Surdacki, Andrzej Dziewierz, Artur Medicina (Kaunas) Article Background and Objectives: Coronary angiography is the gold standard for diagnosing coronary artery disease (CAD). In the case of borderline changes, patients require further diagnosis through ischemia assessment via one of the recommended methods of invasive evaluation. This study aimed to assess whether clinical factors influence the risk of a positive result in invasive myocardial ischemia assessment and if these potential factors change with the patient’s age and the consistency of ischemia assessment. Materials and Methods: Data were collected retrospectively on all consecutive patients hospitalized in the University Hospital in Krakow between 2020 and 2021, on whom physiological assessments of coronary circulation were performed. Patients were divided into two groups: patients aged 60 or younger and patients older than 60. Results: Despite the older patients having more risk factors for CAD, their physiological assessment results of borderline lesions were similar to those of the younger patients. Positive fractional flow reserve (FFR) assessments were obtained from almost 50% of vessels. In the younger patients, cigarette use and type 2 diabetes mellitus increased the risk of a positive FFR result by 3.5 and 2.5 times, respectively. In the older patients, male gender and peripheral vascular disease significantly increased the risk of a positive FFR by 2.5 and 2 times, respectively. Conclusions: Clinical characteristics of patients undergoing physiological assessment of borderline coronary stenosis varied significantly by age. Refining the definition of borderline lesions to include age, gender, and other factors may improve the identification of patients who would benefit from physiological assessment and coronary revascularization. MDPI 2023-10-19 /pmc/articles/PMC10608417/ /pubmed/37893581 http://dx.doi.org/10.3390/medicina59101863 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zasada, Wojciech
Zdzierak, Barbara
Rakowski, Tomasz
Bobrowska, Beata
Krawczyk-Ożóg, Agata
Surowiec, Sławomir
Bartuś, Stanisław
Surdacki, Andrzej
Dziewierz, Artur
The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title_full The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title_fullStr The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title_full_unstemmed The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title_short The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
title_sort impact of age on the physiological assessment of borderline coronary stenoses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608417/
https://www.ncbi.nlm.nih.gov/pubmed/37893581
http://dx.doi.org/10.3390/medicina59101863
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