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The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608421/ https://www.ncbi.nlm.nih.gov/pubmed/37893529 http://dx.doi.org/10.3390/medicina59101811 |
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author | Ozyildirim, Serhan Barman, Hasan Ali Dogan, Omer Ersanli, Murat Kazim Dogan, Sait Mesut |
author_facet | Ozyildirim, Serhan Barman, Hasan Ali Dogan, Omer Ersanli, Murat Kazim Dogan, Sait Mesut |
author_sort | Ozyildirim, Serhan |
collection | PubMed |
description | Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function, are emerging as potential indicators of cardiovascular risk. This study aims to investigate the association between CFR and the TyG index in GDM patients. Materials and Methods: This cross-sectional study of 87 GDM patients and 36 healthy controls was conducted. The participants underwent clinical assessments, blood tests, and echocardiographic evaluations. The TyG index was calculated as ln(triglycerides × fasting glucose/2). CFR was measured using Doppler echocardiography during rest and hyperemia induced by dipyridamole. Results: The study included 87 individuals in the GDM group and 36 individuals in the control group. There was no significant difference in age between the two groups (34.1 ± 5.3 years for GDM vs. 33.1 ± 4.9 years for the control, p = 0.364). The TyG index was significantly higher in the GDM group compared to the controls (p < 0.001). CFR was lower in the GDM group (p < 0.001). A negative correlation between the TyG index and CFR was observed (r = −0.624, p < 0.001). Linear regression revealed the TyG index as an independent predictor of reduced CFR. Conclusions: The study findings reveal a significant association between the TyG index and CFR in GDM patients, suggesting their potential role in assessing cardiovascular risk. |
format | Online Article Text |
id | pubmed-10608421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106084212023-10-28 The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus Ozyildirim, Serhan Barman, Hasan Ali Dogan, Omer Ersanli, Murat Kazim Dogan, Sait Mesut Medicina (Kaunas) Article Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function, are emerging as potential indicators of cardiovascular risk. This study aims to investigate the association between CFR and the TyG index in GDM patients. Materials and Methods: This cross-sectional study of 87 GDM patients and 36 healthy controls was conducted. The participants underwent clinical assessments, blood tests, and echocardiographic evaluations. The TyG index was calculated as ln(triglycerides × fasting glucose/2). CFR was measured using Doppler echocardiography during rest and hyperemia induced by dipyridamole. Results: The study included 87 individuals in the GDM group and 36 individuals in the control group. There was no significant difference in age between the two groups (34.1 ± 5.3 years for GDM vs. 33.1 ± 4.9 years for the control, p = 0.364). The TyG index was significantly higher in the GDM group compared to the controls (p < 0.001). CFR was lower in the GDM group (p < 0.001). A negative correlation between the TyG index and CFR was observed (r = −0.624, p < 0.001). Linear regression revealed the TyG index as an independent predictor of reduced CFR. Conclusions: The study findings reveal a significant association between the TyG index and CFR in GDM patients, suggesting their potential role in assessing cardiovascular risk. MDPI 2023-10-12 /pmc/articles/PMC10608421/ /pubmed/37893529 http://dx.doi.org/10.3390/medicina59101811 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ozyildirim, Serhan Barman, Hasan Ali Dogan, Omer Ersanli, Murat Kazim Dogan, Sait Mesut The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title | The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title_full | The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title_fullStr | The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title_full_unstemmed | The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title_short | The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus |
title_sort | relationship between coronary flow reserve and the tyg index in patients with gestational diabetes mellitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608421/ https://www.ncbi.nlm.nih.gov/pubmed/37893529 http://dx.doi.org/10.3390/medicina59101811 |
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