Cargando…

The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus

Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function,...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozyildirim, Serhan, Barman, Hasan Ali, Dogan, Omer, Ersanli, Murat Kazim, Dogan, Sait Mesut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608421/
https://www.ncbi.nlm.nih.gov/pubmed/37893529
http://dx.doi.org/10.3390/medicina59101811
_version_ 1785127776386285568
author Ozyildirim, Serhan
Barman, Hasan Ali
Dogan, Omer
Ersanli, Murat Kazim
Dogan, Sait Mesut
author_facet Ozyildirim, Serhan
Barman, Hasan Ali
Dogan, Omer
Ersanli, Murat Kazim
Dogan, Sait Mesut
author_sort Ozyildirim, Serhan
collection PubMed
description Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function, are emerging as potential indicators of cardiovascular risk. This study aims to investigate the association between CFR and the TyG index in GDM patients. Materials and Methods: This cross-sectional study of 87 GDM patients and 36 healthy controls was conducted. The participants underwent clinical assessments, blood tests, and echocardiographic evaluations. The TyG index was calculated as ln(triglycerides × fasting glucose/2). CFR was measured using Doppler echocardiography during rest and hyperemia induced by dipyridamole. Results: The study included 87 individuals in the GDM group and 36 individuals in the control group. There was no significant difference in age between the two groups (34.1 ± 5.3 years for GDM vs. 33.1 ± 4.9 years for the control, p = 0.364). The TyG index was significantly higher in the GDM group compared to the controls (p < 0.001). CFR was lower in the GDM group (p < 0.001). A negative correlation between the TyG index and CFR was observed (r = −0.624, p < 0.001). Linear regression revealed the TyG index as an independent predictor of reduced CFR. Conclusions: The study findings reveal a significant association between the TyG index and CFR in GDM patients, suggesting their potential role in assessing cardiovascular risk.
format Online
Article
Text
id pubmed-10608421
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106084212023-10-28 The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus Ozyildirim, Serhan Barman, Hasan Ali Dogan, Omer Ersanli, Murat Kazim Dogan, Sait Mesut Medicina (Kaunas) Article Background and Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder characterized by glucose intolerance during pregnancy. The triglyceride glucose (TyG) index, a marker of insulin resistance, and coronary flow reserve (CFR), a measure of coronary microvascular function, are emerging as potential indicators of cardiovascular risk. This study aims to investigate the association between CFR and the TyG index in GDM patients. Materials and Methods: This cross-sectional study of 87 GDM patients and 36 healthy controls was conducted. The participants underwent clinical assessments, blood tests, and echocardiographic evaluations. The TyG index was calculated as ln(triglycerides × fasting glucose/2). CFR was measured using Doppler echocardiography during rest and hyperemia induced by dipyridamole. Results: The study included 87 individuals in the GDM group and 36 individuals in the control group. There was no significant difference in age between the two groups (34.1 ± 5.3 years for GDM vs. 33.1 ± 4.9 years for the control, p = 0.364). The TyG index was significantly higher in the GDM group compared to the controls (p < 0.001). CFR was lower in the GDM group (p < 0.001). A negative correlation between the TyG index and CFR was observed (r = −0.624, p < 0.001). Linear regression revealed the TyG index as an independent predictor of reduced CFR. Conclusions: The study findings reveal a significant association between the TyG index and CFR in GDM patients, suggesting their potential role in assessing cardiovascular risk. MDPI 2023-10-12 /pmc/articles/PMC10608421/ /pubmed/37893529 http://dx.doi.org/10.3390/medicina59101811 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ozyildirim, Serhan
Barman, Hasan Ali
Dogan, Omer
Ersanli, Murat Kazim
Dogan, Sait Mesut
The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title_full The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title_fullStr The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title_full_unstemmed The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title_short The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus
title_sort relationship between coronary flow reserve and the tyg index in patients with gestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608421/
https://www.ncbi.nlm.nih.gov/pubmed/37893529
http://dx.doi.org/10.3390/medicina59101811
work_keys_str_mv AT ozyildirimserhan therelationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT barmanhasanali therelationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT doganomer therelationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT ersanlimuratkazim therelationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT dogansaitmesut therelationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT ozyildirimserhan relationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT barmanhasanali relationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT doganomer relationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT ersanlimuratkazim relationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus
AT dogansaitmesut relationshipbetweencoronaryflowreserveandthetygindexinpatientswithgestationaldiabetesmellitus