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Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension

Background and Objectives: Osteoprotegerin (OPG), a soluble glycoprotein found in serum, has been associated with both the presence and severity of atherosclerosis. OPG is regarded as the mediator in the process of vascular endothelial dysfunction. Impaired endothelial function has an intimate link...

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Autores principales: Chen, Yen-Liang, Huang, Po-Yu, Tsai, Jen-Pi, Wang, Ji-Hung, Hsu, Bang-Gee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608475/
https://www.ncbi.nlm.nih.gov/pubmed/37893512
http://dx.doi.org/10.3390/medicina59101794
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author Chen, Yen-Liang
Huang, Po-Yu
Tsai, Jen-Pi
Wang, Ji-Hung
Hsu, Bang-Gee
author_facet Chen, Yen-Liang
Huang, Po-Yu
Tsai, Jen-Pi
Wang, Ji-Hung
Hsu, Bang-Gee
author_sort Chen, Yen-Liang
collection PubMed
description Background and Objectives: Osteoprotegerin (OPG), a soluble glycoprotein found in serum, has been associated with both the presence and severity of atherosclerosis. OPG is regarded as the mediator in the process of vascular endothelial dysfunction. Impaired endothelial function has an intimate link with hypertension (HTN) and is associated with significant morbidity and mortality. This study was to investigate the connection between OPG and endothelial dysfunction in patients having HTN. Materials and Methods: There are 102 patients with HTN included. For the purpose of determining the levels of OPG, a commercial enzyme-linked immunosorbent test kit was applied. The vascular reactivity index (VRI), which is assessed via the digital thermal monitoring, provides information on endothelial function. Results: Ten patients with HTN (9.8%) were classified as having poor vascular reactivity (VRI < 1.0), 46 HTN patients (45.1%) as having intermediate vascular reactivity (1.0 ≤ VRI < 2.0), and 46 HTN patients (45.1%) were classified as having high vascular reactivity (VRI ≥ 2.0). A greater serum OPG level (p < 0.001) and older age (p = 0.022) were linked to impaired vascular reactivity. The estimated glomerular filtration rate (r = 0.196, p = 0.048) was positively correlated with VRI values in hypertensive participants, while advanced age (r = −0.222, p = 0.025) and the log-transformed OPG level (log-OPG, r = −0.357, p < 0.001) were negatively correlated with VRI. Serum log-OPG level was shown to be strongly and independently correlated with VRI values in HTN individuals after multivariable forward stepwise linear regression analysis (β = −0.357, adjusted R(2) change = 0.119, p < 0.001). Conclusions: In patients with HTN, serum OPG levels were adversely correlated with VRI and probably had a role in endothelial dysfunction.
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spelling pubmed-106084752023-10-28 Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension Chen, Yen-Liang Huang, Po-Yu Tsai, Jen-Pi Wang, Ji-Hung Hsu, Bang-Gee Medicina (Kaunas) Article Background and Objectives: Osteoprotegerin (OPG), a soluble glycoprotein found in serum, has been associated with both the presence and severity of atherosclerosis. OPG is regarded as the mediator in the process of vascular endothelial dysfunction. Impaired endothelial function has an intimate link with hypertension (HTN) and is associated with significant morbidity and mortality. This study was to investigate the connection between OPG and endothelial dysfunction in patients having HTN. Materials and Methods: There are 102 patients with HTN included. For the purpose of determining the levels of OPG, a commercial enzyme-linked immunosorbent test kit was applied. The vascular reactivity index (VRI), which is assessed via the digital thermal monitoring, provides information on endothelial function. Results: Ten patients with HTN (9.8%) were classified as having poor vascular reactivity (VRI < 1.0), 46 HTN patients (45.1%) as having intermediate vascular reactivity (1.0 ≤ VRI < 2.0), and 46 HTN patients (45.1%) were classified as having high vascular reactivity (VRI ≥ 2.0). A greater serum OPG level (p < 0.001) and older age (p = 0.022) were linked to impaired vascular reactivity. The estimated glomerular filtration rate (r = 0.196, p = 0.048) was positively correlated with VRI values in hypertensive participants, while advanced age (r = −0.222, p = 0.025) and the log-transformed OPG level (log-OPG, r = −0.357, p < 0.001) were negatively correlated with VRI. Serum log-OPG level was shown to be strongly and independently correlated with VRI values in HTN individuals after multivariable forward stepwise linear regression analysis (β = −0.357, adjusted R(2) change = 0.119, p < 0.001). Conclusions: In patients with HTN, serum OPG levels were adversely correlated with VRI and probably had a role in endothelial dysfunction. MDPI 2023-10-09 /pmc/articles/PMC10608475/ /pubmed/37893512 http://dx.doi.org/10.3390/medicina59101794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yen-Liang
Huang, Po-Yu
Tsai, Jen-Pi
Wang, Ji-Hung
Hsu, Bang-Gee
Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title_full Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title_fullStr Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title_full_unstemmed Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title_short Serum Osteoprotegerin Levels and the Vascular Reactivity Index in Patients with Hypertension
title_sort serum osteoprotegerin levels and the vascular reactivity index in patients with hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608475/
https://www.ncbi.nlm.nih.gov/pubmed/37893512
http://dx.doi.org/10.3390/medicina59101794
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