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Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications

Bowiea volubilis subsp. volubilis is primarily used to address human respiratory infections, coughs, and colds due to its diverse pharmaceutical properties. Notably, the plant contains alkaloids that exhibit notable antifungal, antibacterial, and cytotoxic properties. Additionally, the presence of s...

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Autores principales: Gwanya, Hlalanathi, Cawe, Sizwe, Egbichi, Ifeanyi, Gxaba, Nomagugu, Mbuyiswa, Afika-Amazizi, Zonyane, Samkele, Mbolekwa, Babalwa, Manganyi, Madira C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608581/
https://www.ncbi.nlm.nih.gov/pubmed/37895462
http://dx.doi.org/10.3390/life13102081
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author Gwanya, Hlalanathi
Cawe, Sizwe
Egbichi, Ifeanyi
Gxaba, Nomagugu
Mbuyiswa, Afika-Amazizi
Zonyane, Samkele
Mbolekwa, Babalwa
Manganyi, Madira C.
author_facet Gwanya, Hlalanathi
Cawe, Sizwe
Egbichi, Ifeanyi
Gxaba, Nomagugu
Mbuyiswa, Afika-Amazizi
Zonyane, Samkele
Mbolekwa, Babalwa
Manganyi, Madira C.
author_sort Gwanya, Hlalanathi
collection PubMed
description Bowiea volubilis subsp. volubilis is primarily used to address human respiratory infections, coughs, and colds due to its diverse pharmaceutical properties. Notably, the plant contains alkaloids that exhibit notable antifungal, antibacterial, and cytotoxic properties. Additionally, the presence of saponins, with recognized antioxidant and anticancer attributes, further contributes to its medicinal potential. Steroid compounds inherent to the plant have been associated with anti-inflammatory and anticancer activities. Moreover, the bulb of B. volubilis has been associated as a source of various cardiac glycosides. Despite these therapeutic prospects, B. volubilis remains inedible due to the presence of naturally occurring toxic substances that pose risks to both animals and humans. The review focuses on a comprehensive exploration concerning B. volubilis ethnobotanical applications, phytochemical properties, and diverse biological activities in relation to in vitro and in vivo applications for promoting human health and disease prevention. The aim of the study is to comprehensively investigate the phytochemical composition, bioactive compounds, and potential medicinal properties of Bowiea volubilis, with the ultimate goal of uncovering its therapeutic applications for human health. This review also highlights an evident gap in research, i.e., insufficient evidence-based research on toxicity data. This void in knowledge presents a promising avenue for future investigations, opening doors to expanded inquiries into the properties and potential applications of B. volubilis in the context of human diseases.
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spelling pubmed-106085812023-10-28 Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications Gwanya, Hlalanathi Cawe, Sizwe Egbichi, Ifeanyi Gxaba, Nomagugu Mbuyiswa, Afika-Amazizi Zonyane, Samkele Mbolekwa, Babalwa Manganyi, Madira C. Life (Basel) Review Bowiea volubilis subsp. volubilis is primarily used to address human respiratory infections, coughs, and colds due to its diverse pharmaceutical properties. Notably, the plant contains alkaloids that exhibit notable antifungal, antibacterial, and cytotoxic properties. Additionally, the presence of saponins, with recognized antioxidant and anticancer attributes, further contributes to its medicinal potential. Steroid compounds inherent to the plant have been associated with anti-inflammatory and anticancer activities. Moreover, the bulb of B. volubilis has been associated as a source of various cardiac glycosides. Despite these therapeutic prospects, B. volubilis remains inedible due to the presence of naturally occurring toxic substances that pose risks to both animals and humans. The review focuses on a comprehensive exploration concerning B. volubilis ethnobotanical applications, phytochemical properties, and diverse biological activities in relation to in vitro and in vivo applications for promoting human health and disease prevention. The aim of the study is to comprehensively investigate the phytochemical composition, bioactive compounds, and potential medicinal properties of Bowiea volubilis, with the ultimate goal of uncovering its therapeutic applications for human health. This review also highlights an evident gap in research, i.e., insufficient evidence-based research on toxicity data. This void in knowledge presents a promising avenue for future investigations, opening doors to expanded inquiries into the properties and potential applications of B. volubilis in the context of human diseases. MDPI 2023-10-19 /pmc/articles/PMC10608581/ /pubmed/37895462 http://dx.doi.org/10.3390/life13102081 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gwanya, Hlalanathi
Cawe, Sizwe
Egbichi, Ifeanyi
Gxaba, Nomagugu
Mbuyiswa, Afika-Amazizi
Zonyane, Samkele
Mbolekwa, Babalwa
Manganyi, Madira C.
Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title_full Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title_fullStr Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title_full_unstemmed Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title_short Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications
title_sort bowiea volubilis: from “climbing onion” to therapeutic treasure—exploring human health applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608581/
https://www.ncbi.nlm.nih.gov/pubmed/37895462
http://dx.doi.org/10.3390/life13102081
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