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Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology

Background: Osseous tissue in the endometrium is a rare find, and it is most often discovered when the patient presents with infertility. It is frequently associated with dysmenorrhea and abnormal menstrual bleedings. Although its etiology remains unclear, in almost all described cases until now, th...

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Autores principales: Tica, Vlad Iustin, Postolache, Iulia, Boșoteanu, Madalina, Aschie, Mariana, Tica, Irina, Orasanu, Cristian Ionut, Penciu, Roxana Cleopatra, Tica, Andrei Adrian, Steriu, Liliana, De Wilde, Rudy Leon, Tica, Oana Sorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608607/
https://www.ncbi.nlm.nih.gov/pubmed/37893521
http://dx.doi.org/10.3390/medicina59101803
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author Tica, Vlad Iustin
Postolache, Iulia
Boșoteanu, Madalina
Aschie, Mariana
Tica, Irina
Orasanu, Cristian Ionut
Penciu, Roxana Cleopatra
Tica, Andrei Adrian
Steriu, Liliana
De Wilde, Rudy Leon
Tica, Oana Sorina
author_facet Tica, Vlad Iustin
Postolache, Iulia
Boșoteanu, Madalina
Aschie, Mariana
Tica, Irina
Orasanu, Cristian Ionut
Penciu, Roxana Cleopatra
Tica, Andrei Adrian
Steriu, Liliana
De Wilde, Rudy Leon
Tica, Oana Sorina
author_sort Tica, Vlad Iustin
collection PubMed
description Background: Osseous tissue in the endometrium is a rare find, and it is most often discovered when the patient presents with infertility. It is frequently associated with dysmenorrhea and abnormal menstrual bleedings. Although its etiology remains unclear, in almost all described cases until now, the patient has an obstetrical history. Case report: In this report, we present a unique case of endometrial osseous metaplasia in a 27-year-old primary infertile patient. The transvaginal ultrasound revealed a 18/13/7 mm hyperechoic endometrial mass with posterior acoustic shadowing and no flow on color Doppler. A hysteroscopic examination found a polygonal calcification on the endometrial posterior face of the uterine cavity, in the corporeal isthmic region, which was extracted. The histopathological evaluation revealed microscopic elements compatible with endometrial calcification. The patient had a good postoperative course and the complex endocrinologic, immunologic and electrolytical investigation failed to prove any abnormality. Follow-up transvaginal ultrasound examinations revealed no modifications. Three years later, the patient conceived spontaneously, had an uneventful pregnancy and delivered a full-term fetus. Conclusion: We assumed that this entity can be a serious cause of infertility since the patient had a long history of (primary) infertility and its resection made the pregnancy’s occurrence possible. Finally, since neither history of abortion or chronic inflammation nor any abnormal laboratory test were noticed, we concluded that the etiology of this entity remained unclear.
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spelling pubmed-106086072023-10-28 Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology Tica, Vlad Iustin Postolache, Iulia Boșoteanu, Madalina Aschie, Mariana Tica, Irina Orasanu, Cristian Ionut Penciu, Roxana Cleopatra Tica, Andrei Adrian Steriu, Liliana De Wilde, Rudy Leon Tica, Oana Sorina Medicina (Kaunas) Case Report Background: Osseous tissue in the endometrium is a rare find, and it is most often discovered when the patient presents with infertility. It is frequently associated with dysmenorrhea and abnormal menstrual bleedings. Although its etiology remains unclear, in almost all described cases until now, the patient has an obstetrical history. Case report: In this report, we present a unique case of endometrial osseous metaplasia in a 27-year-old primary infertile patient. The transvaginal ultrasound revealed a 18/13/7 mm hyperechoic endometrial mass with posterior acoustic shadowing and no flow on color Doppler. A hysteroscopic examination found a polygonal calcification on the endometrial posterior face of the uterine cavity, in the corporeal isthmic region, which was extracted. The histopathological evaluation revealed microscopic elements compatible with endometrial calcification. The patient had a good postoperative course and the complex endocrinologic, immunologic and electrolytical investigation failed to prove any abnormality. Follow-up transvaginal ultrasound examinations revealed no modifications. Three years later, the patient conceived spontaneously, had an uneventful pregnancy and delivered a full-term fetus. Conclusion: We assumed that this entity can be a serious cause of infertility since the patient had a long history of (primary) infertility and its resection made the pregnancy’s occurrence possible. Finally, since neither history of abortion or chronic inflammation nor any abnormal laboratory test were noticed, we concluded that the etiology of this entity remained unclear. MDPI 2023-10-10 /pmc/articles/PMC10608607/ /pubmed/37893521 http://dx.doi.org/10.3390/medicina59101803 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tica, Vlad Iustin
Postolache, Iulia
Boșoteanu, Madalina
Aschie, Mariana
Tica, Irina
Orasanu, Cristian Ionut
Penciu, Roxana Cleopatra
Tica, Andrei Adrian
Steriu, Liliana
De Wilde, Rudy Leon
Tica, Oana Sorina
Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title_full Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title_fullStr Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title_full_unstemmed Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title_short Endometrial Osseous Metaplasia—A Rare Cause of Infertility with Unknown Etiology
title_sort endometrial osseous metaplasia—a rare cause of infertility with unknown etiology
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608607/
https://www.ncbi.nlm.nih.gov/pubmed/37893521
http://dx.doi.org/10.3390/medicina59101803
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