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Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report

Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiot...

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Autores principales: Kurtov, Marija, Kilić, Paula, Ikić, Lucija, Kurtov, Karlo, Dorčić, Gordan, Vodanović, Marko, Artuković, Marinko, Ikić Matijašević, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608669/
https://www.ncbi.nlm.nih.gov/pubmed/37893502
http://dx.doi.org/10.3390/medicina59101784
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author Kurtov, Marija
Kilić, Paula
Ikić, Lucija
Kurtov, Karlo
Dorčić, Gordan
Vodanović, Marko
Artuković, Marinko
Ikić Matijašević, Marina
author_facet Kurtov, Marija
Kilić, Paula
Ikić, Lucija
Kurtov, Karlo
Dorčić, Gordan
Vodanović, Marko
Artuković, Marinko
Ikić Matijašević, Marina
author_sort Kurtov, Marija
collection PubMed
description Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required.
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spelling pubmed-106086692023-10-28 Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report Kurtov, Marija Kilić, Paula Ikić, Lucija Kurtov, Karlo Dorčić, Gordan Vodanović, Marko Artuković, Marinko Ikić Matijašević, Marina Medicina (Kaunas) Case Report Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required. MDPI 2023-10-07 /pmc/articles/PMC10608669/ /pubmed/37893502 http://dx.doi.org/10.3390/medicina59101784 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kurtov, Marija
Kilić, Paula
Ikić, Lucija
Kurtov, Karlo
Dorčić, Gordan
Vodanović, Marko
Artuković, Marinko
Ikić Matijašević, Marina
Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title_full Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title_fullStr Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title_full_unstemmed Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title_short Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report
title_sort ciprofloxacin-induced anaphylactic reaction followed by negative provocation test in response to levofloxacin: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608669/
https://www.ncbi.nlm.nih.gov/pubmed/37893502
http://dx.doi.org/10.3390/medicina59101784
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