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The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI

Background and Objectives: Vasa previa (VP) is a significant perinatal complication that can have serious consequences for the fetus/neonate. Velamentous cord insertion (VCI) is a crucial finding in prenatal placental morphology surveillance as it is indicative of comorbid VP. Assisted reproductive...

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Autores principales: Fukuda, Eriko, Hamuro, Akihiro, Kitada, Kohei, Kurihara, Yasushi, Tahara, Mie, Misugi, Takuya, Nakano, Akemi, Tamaue, Mami, Shinomiya, Sae, Yoshida, Hisako, Koyama, Masayasu, Tachibana, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608747/
https://www.ncbi.nlm.nih.gov/pubmed/37893433
http://dx.doi.org/10.3390/medicina59101715
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author Fukuda, Eriko
Hamuro, Akihiro
Kitada, Kohei
Kurihara, Yasushi
Tahara, Mie
Misugi, Takuya
Nakano, Akemi
Tamaue, Mami
Shinomiya, Sae
Yoshida, Hisako
Koyama, Masayasu
Tachibana, Daisuke
author_facet Fukuda, Eriko
Hamuro, Akihiro
Kitada, Kohei
Kurihara, Yasushi
Tahara, Mie
Misugi, Takuya
Nakano, Akemi
Tamaue, Mami
Shinomiya, Sae
Yoshida, Hisako
Koyama, Masayasu
Tachibana, Daisuke
author_sort Fukuda, Eriko
collection PubMed
description Background and Objectives: Vasa previa (VP) is a significant perinatal complication that can have serious consequences for the fetus/neonate. Velamentous cord insertion (VCI) is a crucial finding in prenatal placental morphology surveillance as it is indicative of comorbid VP. Assisted reproductive technology (ART) has been identified as a risk factor for VCI, so identifying risk factors for VCI in ART could improve VP recognition. This study aims to evaluate the displacement of umbilical cord insertion (CI) from the placental center and to examine the relationship between the modes of conception. Materials and Methods: We conducted a retrospective study at the Obstetrics Department of Osaka Metropolitan University Hospital in Japan between May 2020 and June 2022. The study included a total of 1102 patients who delivered after 22 weeks of gestation. They were divided into three groups: spontaneous pregnancy, conventional in vitro fertilization (cIVF), and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We recorded patient background information, perinatal complications, perinatal outcomes, and a numerical “displacement score”, indicating the degree of separation between umbilical CI and the placental center. Results: The displacement score was significantly higher in the cIVF and IVF/ICSI groups compared with the spontaneous conception group. Additionally, the IVF/ICSI group showed a significantly higher displacement score than the cIVF group. Conclusions: Our study provides the first evidence that the methods of ART can affect the location of umbilical CI on the placental surface. Furthermore, we found that IVF/ICSI may contribute to greater displacement of CI from the placental center.
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spelling pubmed-106087472023-10-28 The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI Fukuda, Eriko Hamuro, Akihiro Kitada, Kohei Kurihara, Yasushi Tahara, Mie Misugi, Takuya Nakano, Akemi Tamaue, Mami Shinomiya, Sae Yoshida, Hisako Koyama, Masayasu Tachibana, Daisuke Medicina (Kaunas) Article Background and Objectives: Vasa previa (VP) is a significant perinatal complication that can have serious consequences for the fetus/neonate. Velamentous cord insertion (VCI) is a crucial finding in prenatal placental morphology surveillance as it is indicative of comorbid VP. Assisted reproductive technology (ART) has been identified as a risk factor for VCI, so identifying risk factors for VCI in ART could improve VP recognition. This study aims to evaluate the displacement of umbilical cord insertion (CI) from the placental center and to examine the relationship between the modes of conception. Materials and Methods: We conducted a retrospective study at the Obstetrics Department of Osaka Metropolitan University Hospital in Japan between May 2020 and June 2022. The study included a total of 1102 patients who delivered after 22 weeks of gestation. They were divided into three groups: spontaneous pregnancy, conventional in vitro fertilization (cIVF), and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We recorded patient background information, perinatal complications, perinatal outcomes, and a numerical “displacement score”, indicating the degree of separation between umbilical CI and the placental center. Results: The displacement score was significantly higher in the cIVF and IVF/ICSI groups compared with the spontaneous conception group. Additionally, the IVF/ICSI group showed a significantly higher displacement score than the cIVF group. Conclusions: Our study provides the first evidence that the methods of ART can affect the location of umbilical CI on the placental surface. Furthermore, we found that IVF/ICSI may contribute to greater displacement of CI from the placental center. MDPI 2023-09-25 /pmc/articles/PMC10608747/ /pubmed/37893433 http://dx.doi.org/10.3390/medicina59101715 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fukuda, Eriko
Hamuro, Akihiro
Kitada, Kohei
Kurihara, Yasushi
Tahara, Mie
Misugi, Takuya
Nakano, Akemi
Tamaue, Mami
Shinomiya, Sae
Yoshida, Hisako
Koyama, Masayasu
Tachibana, Daisuke
The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title_full The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title_fullStr The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title_full_unstemmed The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title_short The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI
title_sort impact of assisted reproductive technology on umbilical cord insertion: increased risk of velamentous cord insertion in singleton pregnancies conceived through icsi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608747/
https://www.ncbi.nlm.nih.gov/pubmed/37893433
http://dx.doi.org/10.3390/medicina59101715
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