Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species

Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by Paracoccidioides ceti. Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cr...

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Autores principales: Kanegae, Hikaru, de Souza Suguiura, Igor Massahiro, Tashiro, Rentaro, Konno, Toshihiro, Hou, De-Xing, Sano, Ayako, Eto, Takeshi, Ueda, Keiichi, Hossain, Md. Amzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609003/
https://www.ncbi.nlm.nih.gov/pubmed/37894086
http://dx.doi.org/10.3390/microorganisms11102428
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author Kanegae, Hikaru
de Souza Suguiura, Igor Massahiro
Tashiro, Rentaro
Konno, Toshihiro
Hou, De-Xing
Sano, Ayako
Eto, Takeshi
Ueda, Keiichi
Hossain, Md. Amzad
author_facet Kanegae, Hikaru
de Souza Suguiura, Igor Massahiro
Tashiro, Rentaro
Konno, Toshihiro
Hou, De-Xing
Sano, Ayako
Eto, Takeshi
Ueda, Keiichi
Hossain, Md. Amzad
author_sort Kanegae, Hikaru
collection PubMed
description Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by Paracoccidioides ceti. Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against P. ceti has remained unknown due to the use of positive control sera from infected dolphins. This study aimed to re-evaluate antibodies from mechanically dislodged fungal cells in the infected tissue of a PCM-C case and demonstrate the actual cross-reaction. The results revealed a limited cross-reaction between PCM-C and paracoccidioidomycosis, while the antibodies did not react with other pathogens such as Coccidioides posadasii, Histoplasama capsulatum, and Arthrographis kalrae. Thus, the method for evaluation of the antibody against PCM-C is reliable, and there is potential for epidemiological study.
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spelling pubmed-106090032023-10-28 Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species Kanegae, Hikaru de Souza Suguiura, Igor Massahiro Tashiro, Rentaro Konno, Toshihiro Hou, De-Xing Sano, Ayako Eto, Takeshi Ueda, Keiichi Hossain, Md. Amzad Microorganisms Communication Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by Paracoccidioides ceti. Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against P. ceti has remained unknown due to the use of positive control sera from infected dolphins. This study aimed to re-evaluate antibodies from mechanically dislodged fungal cells in the infected tissue of a PCM-C case and demonstrate the actual cross-reaction. The results revealed a limited cross-reaction between PCM-C and paracoccidioidomycosis, while the antibodies did not react with other pathogens such as Coccidioides posadasii, Histoplasama capsulatum, and Arthrographis kalrae. Thus, the method for evaluation of the antibody against PCM-C is reliable, and there is potential for epidemiological study. MDPI 2023-09-28 /pmc/articles/PMC10609003/ /pubmed/37894086 http://dx.doi.org/10.3390/microorganisms11102428 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kanegae, Hikaru
de Souza Suguiura, Igor Massahiro
Tashiro, Rentaro
Konno, Toshihiro
Hou, De-Xing
Sano, Ayako
Eto, Takeshi
Ueda, Keiichi
Hossain, Md. Amzad
Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title_full Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title_fullStr Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title_full_unstemmed Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title_short Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species
title_sort re-evaluation of the cross-reactions of the antibody against the causative agent for paracoccidioidomycosis ceti; paracoccidioides ceti and the related fungal species
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609003/
https://www.ncbi.nlm.nih.gov/pubmed/37894086
http://dx.doi.org/10.3390/microorganisms11102428
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