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Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance
Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic neuroscience research to providing an intimate interface with the brain as part of a brain-computer interface (BCI) system aimed at restoring function for people living with neurological disorders or injuri...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609067/ https://www.ncbi.nlm.nih.gov/pubmed/37893339 http://dx.doi.org/10.3390/mi14101902 |
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author | Hoeferlin, George F. Bajwa, Tejas Olivares, Hannah Zhang, Jichu Druschel, Lindsey N. Sturgill, Brandon S. Sobota, Michael Boucher, Pierce Duncan, Jonathan Hernandez-Reynoso, Ana G. Cogan, Stuart F. Pancrazio, Joseph J. Capadona, Jeffrey R. |
author_facet | Hoeferlin, George F. Bajwa, Tejas Olivares, Hannah Zhang, Jichu Druschel, Lindsey N. Sturgill, Brandon S. Sobota, Michael Boucher, Pierce Duncan, Jonathan Hernandez-Reynoso, Ana G. Cogan, Stuart F. Pancrazio, Joseph J. Capadona, Jeffrey R. |
author_sort | Hoeferlin, George F. |
collection | PubMed |
description | Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic neuroscience research to providing an intimate interface with the brain as part of a brain-computer interface (BCI) system aimed at restoring function for people living with neurological disorders or injuries. Unfortunately, MEAs tend to fail prematurely, leading to a loss in functionality for many applications. An important contributing factor in MEA failure is oxidative stress resulting from chronically inflammatory-activated microglia and macrophages releasing reactive oxygen species (ROS) around the implant site. Antioxidants offer a means for mitigating oxidative stress and improving tissue health and MEA performance. Here, we investigate using the clinically available antioxidant dimethyl fumarate (DMF) to reduce the neuroinflammatory response and improve MEA performance in a rat MEA model. Daily treatment of DMF for 16 weeks resulted in a significant improvement in the recording capabilities of MEA devices during the sub-chronic (Weeks 5–11) phase (42% active electrode yield vs. 35% for control). However, these sub-chronic improvements were lost in the chronic implantation phase, as a more exacerbated neuroinflammatory response occurs in DMF-treated animals by 16 weeks post-implantation. Yet, neuroinflammation was indiscriminate between treatment and control groups during the sub-chronic phase. Although worse for chronic use, a temporary improvement (<12 weeks) in MEA performance is meaningful. Providing short-term improvement to MEA devices using DMF can allow for improved use for limited-duration studies. Further efforts should be taken to explore the mechanism behind a worsened neuroinflammatory response at the 16-week time point for DMF-treated animals and assess its usefulness for specific applications. |
format | Online Article Text |
id | pubmed-10609067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106090672023-10-28 Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance Hoeferlin, George F. Bajwa, Tejas Olivares, Hannah Zhang, Jichu Druschel, Lindsey N. Sturgill, Brandon S. Sobota, Michael Boucher, Pierce Duncan, Jonathan Hernandez-Reynoso, Ana G. Cogan, Stuart F. Pancrazio, Joseph J. Capadona, Jeffrey R. Micromachines (Basel) Article Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic neuroscience research to providing an intimate interface with the brain as part of a brain-computer interface (BCI) system aimed at restoring function for people living with neurological disorders or injuries. Unfortunately, MEAs tend to fail prematurely, leading to a loss in functionality for many applications. An important contributing factor in MEA failure is oxidative stress resulting from chronically inflammatory-activated microglia and macrophages releasing reactive oxygen species (ROS) around the implant site. Antioxidants offer a means for mitigating oxidative stress and improving tissue health and MEA performance. Here, we investigate using the clinically available antioxidant dimethyl fumarate (DMF) to reduce the neuroinflammatory response and improve MEA performance in a rat MEA model. Daily treatment of DMF for 16 weeks resulted in a significant improvement in the recording capabilities of MEA devices during the sub-chronic (Weeks 5–11) phase (42% active electrode yield vs. 35% for control). However, these sub-chronic improvements were lost in the chronic implantation phase, as a more exacerbated neuroinflammatory response occurs in DMF-treated animals by 16 weeks post-implantation. Yet, neuroinflammation was indiscriminate between treatment and control groups during the sub-chronic phase. Although worse for chronic use, a temporary improvement (<12 weeks) in MEA performance is meaningful. Providing short-term improvement to MEA devices using DMF can allow for improved use for limited-duration studies. Further efforts should be taken to explore the mechanism behind a worsened neuroinflammatory response at the 16-week time point for DMF-treated animals and assess its usefulness for specific applications. MDPI 2023-10-04 /pmc/articles/PMC10609067/ /pubmed/37893339 http://dx.doi.org/10.3390/mi14101902 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hoeferlin, George F. Bajwa, Tejas Olivares, Hannah Zhang, Jichu Druschel, Lindsey N. Sturgill, Brandon S. Sobota, Michael Boucher, Pierce Duncan, Jonathan Hernandez-Reynoso, Ana G. Cogan, Stuart F. Pancrazio, Joseph J. Capadona, Jeffrey R. Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title | Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title_full | Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title_fullStr | Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title_full_unstemmed | Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title_short | Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance |
title_sort | antioxidant dimethyl fumarate temporarily but not chronically improves intracortical microelectrode performance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609067/ https://www.ncbi.nlm.nih.gov/pubmed/37893339 http://dx.doi.org/10.3390/mi14101902 |
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