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Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential

Non-tuberculous mycobacteria (NTM) are opportunistic pathogens capable of causing infections in humans and animals. The aim of this study was to demonstrate the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly growing NTM strains representing a potential zoon...

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Autores principales: Reil, Irena, Špičić, Silvio, Barbić, Ljubo, Duvnjak, Sanja, Kompes, Gordan, Benić, Miroslav, Stojević, Dora, Cvetnić, Željko, Arapović, Jurica, Zdelar-Tuk, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609087/
https://www.ncbi.nlm.nih.gov/pubmed/37894179
http://dx.doi.org/10.3390/microorganisms11102520
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author Reil, Irena
Špičić, Silvio
Barbić, Ljubo
Duvnjak, Sanja
Kompes, Gordan
Benić, Miroslav
Stojević, Dora
Cvetnić, Željko
Arapović, Jurica
Zdelar-Tuk, Maja
author_facet Reil, Irena
Špičić, Silvio
Barbić, Ljubo
Duvnjak, Sanja
Kompes, Gordan
Benić, Miroslav
Stojević, Dora
Cvetnić, Željko
Arapović, Jurica
Zdelar-Tuk, Maja
author_sort Reil, Irena
collection PubMed
description Non-tuberculous mycobacteria (NTM) are opportunistic pathogens capable of causing infections in humans and animals. The aim of this study was to demonstrate the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly growing NTM strains representing a potential zoonotic threat to humans. A total of 87 animal isolates belonging to 11 rapidly growing species (visible colonies appear within three to seven days) were genotyped and tested for susceptibility to the 15 most commonly used antibiotics in the treatment of such infections in a human clinic. By determining the antimicrobial susceptibility, the most prevalent resistance was found to cephalosporins (>50%), followed by amoxicillin–clavulanate (31.0%), clarithromycin (23.0%), tobramycin (14.9%) and doxycycline (10.3%). Resistance to imipenem, ciprofloxacin, minocycline and linezolid was notably lower (<7.0%). All tested isolates were susceptible to amikacin and moxifloxacin. The most frequent resistance was proved in the most pathogenic species: M. fortuitum, M. neoaurum, M. vaccae and M. porcinum. Meanwhile, other species displayed a higher sensitivity rate. No significant resistance differences between domestic and wild animals were found. The established significant frequency of resistance highlights the significant zoonotic potential posed by circulating rapidly growing NTM strains, which could lead to challenges in the treatment of these infections.
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spelling pubmed-106090872023-10-28 Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential Reil, Irena Špičić, Silvio Barbić, Ljubo Duvnjak, Sanja Kompes, Gordan Benić, Miroslav Stojević, Dora Cvetnić, Željko Arapović, Jurica Zdelar-Tuk, Maja Microorganisms Article Non-tuberculous mycobacteria (NTM) are opportunistic pathogens capable of causing infections in humans and animals. The aim of this study was to demonstrate the potential role of domestic and wild animals as a reservoir of multiple resistant, rapidly growing NTM strains representing a potential zoonotic threat to humans. A total of 87 animal isolates belonging to 11 rapidly growing species (visible colonies appear within three to seven days) were genotyped and tested for susceptibility to the 15 most commonly used antibiotics in the treatment of such infections in a human clinic. By determining the antimicrobial susceptibility, the most prevalent resistance was found to cephalosporins (>50%), followed by amoxicillin–clavulanate (31.0%), clarithromycin (23.0%), tobramycin (14.9%) and doxycycline (10.3%). Resistance to imipenem, ciprofloxacin, minocycline and linezolid was notably lower (<7.0%). All tested isolates were susceptible to amikacin and moxifloxacin. The most frequent resistance was proved in the most pathogenic species: M. fortuitum, M. neoaurum, M. vaccae and M. porcinum. Meanwhile, other species displayed a higher sensitivity rate. No significant resistance differences between domestic and wild animals were found. The established significant frequency of resistance highlights the significant zoonotic potential posed by circulating rapidly growing NTM strains, which could lead to challenges in the treatment of these infections. MDPI 2023-10-09 /pmc/articles/PMC10609087/ /pubmed/37894179 http://dx.doi.org/10.3390/microorganisms11102520 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reil, Irena
Špičić, Silvio
Barbić, Ljubo
Duvnjak, Sanja
Kompes, Gordan
Benić, Miroslav
Stojević, Dora
Cvetnić, Željko
Arapović, Jurica
Zdelar-Tuk, Maja
Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title_full Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title_fullStr Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title_full_unstemmed Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title_short Antimicrobial Resistance in Rapidly Growing Nontuberculous Mycobacteria among Domestic and Wild Animals Emphasizing the Zoonotic Potential
title_sort antimicrobial resistance in rapidly growing nontuberculous mycobacteria among domestic and wild animals emphasizing the zoonotic potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609087/
https://www.ncbi.nlm.nih.gov/pubmed/37894179
http://dx.doi.org/10.3390/microorganisms11102520
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