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The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study

Background: The Pancreatic Stone Protein (PSP) is an acute-phase protein that is mainly secreted by pancreatic cells in response to stress. The current literature supports its use as a predictor of sepsis. Its prognostic role has recently been evaluated in a point-of-care setting, mostly in high-ris...

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Autores principales: Michailides, Christos, Lagadinou, Maria, Paraskevas, Themistoklis, Papantoniou, Konstantinos, Kavvousanos, Michael, Vasileiou, Achilleas, Thomopoulos, Konstantinos, Velissaris, Dimitrios, Marangos, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609141/
https://www.ncbi.nlm.nih.gov/pubmed/37894237
http://dx.doi.org/10.3390/microorganisms11102579
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author Michailides, Christos
Lagadinou, Maria
Paraskevas, Themistoklis
Papantoniou, Konstantinos
Kavvousanos, Michael
Vasileiou, Achilleas
Thomopoulos, Konstantinos
Velissaris, Dimitrios
Marangos, Markos
author_facet Michailides, Christos
Lagadinou, Maria
Paraskevas, Themistoklis
Papantoniou, Konstantinos
Kavvousanos, Michael
Vasileiou, Achilleas
Thomopoulos, Konstantinos
Velissaris, Dimitrios
Marangos, Markos
author_sort Michailides, Christos
collection PubMed
description Background: The Pancreatic Stone Protein (PSP) is an acute-phase protein that is mainly secreted by pancreatic cells in response to stress. The current literature supports its use as a predictor of sepsis. Its prognostic role has recently been evaluated in a point-of-care setting, mostly in high-risk patients. We conducted a prospective observational cohort study to evaluate its utility in the prognosis of patients admitted to the hospital with a diagnosis of intra-abdominal infection. Methods: Adult patients consecutively admitted to the Internal Medicine Department of the University Hospital of Patras, Greece, with a diagnosis of intra-abdominal infection were enrolled. PSP levels were measured within 24 h of admission in whole blood. Results: a total of 40 patients were included after being diagnosed with IAI. PSP was used as an independent predictive factor for sepsis after adjusting for age with OR = 7.888 (95% CI: 1.247–49.890). PSP also predicted readmission and the need for treatment escalation (p: <0.01) and was an excellent prognostic factor regarding these outcomes (AUC = 0.899, 95% CI: 0.794–1.0, and AUC = 0.862, 95% CI: 0.748–0.976, respectively). PSP also proved superior to CRP, ferritin, and fibrinogen in sepsis diagnosis, treatment escalation, and readmission prediction with an AUC of 0.862, 0.698, and 0.899, respectively. Conclusions: PSP can predict unfavorable outcomes, such as sepsis development, readmission, and the need for treatment escalation among patients with intra-abdominal infections.
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spelling pubmed-106091412023-10-28 The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study Michailides, Christos Lagadinou, Maria Paraskevas, Themistoklis Papantoniou, Konstantinos Kavvousanos, Michael Vasileiou, Achilleas Thomopoulos, Konstantinos Velissaris, Dimitrios Marangos, Markos Microorganisms Communication Background: The Pancreatic Stone Protein (PSP) is an acute-phase protein that is mainly secreted by pancreatic cells in response to stress. The current literature supports its use as a predictor of sepsis. Its prognostic role has recently been evaluated in a point-of-care setting, mostly in high-risk patients. We conducted a prospective observational cohort study to evaluate its utility in the prognosis of patients admitted to the hospital with a diagnosis of intra-abdominal infection. Methods: Adult patients consecutively admitted to the Internal Medicine Department of the University Hospital of Patras, Greece, with a diagnosis of intra-abdominal infection were enrolled. PSP levels were measured within 24 h of admission in whole blood. Results: a total of 40 patients were included after being diagnosed with IAI. PSP was used as an independent predictive factor for sepsis after adjusting for age with OR = 7.888 (95% CI: 1.247–49.890). PSP also predicted readmission and the need for treatment escalation (p: <0.01) and was an excellent prognostic factor regarding these outcomes (AUC = 0.899, 95% CI: 0.794–1.0, and AUC = 0.862, 95% CI: 0.748–0.976, respectively). PSP also proved superior to CRP, ferritin, and fibrinogen in sepsis diagnosis, treatment escalation, and readmission prediction with an AUC of 0.862, 0.698, and 0.899, respectively. Conclusions: PSP can predict unfavorable outcomes, such as sepsis development, readmission, and the need for treatment escalation among patients with intra-abdominal infections. MDPI 2023-10-17 /pmc/articles/PMC10609141/ /pubmed/37894237 http://dx.doi.org/10.3390/microorganisms11102579 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Michailides, Christos
Lagadinou, Maria
Paraskevas, Themistoklis
Papantoniou, Konstantinos
Kavvousanos, Michael
Vasileiou, Achilleas
Thomopoulos, Konstantinos
Velissaris, Dimitrios
Marangos, Markos
The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title_full The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title_fullStr The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title_full_unstemmed The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title_short The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study
title_sort role of the pancreatic stone protein in predicting intra-abdominal infection-related complications: a prospective observational single-center cohort study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609141/
https://www.ncbi.nlm.nih.gov/pubmed/37894237
http://dx.doi.org/10.3390/microorganisms11102579
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