Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease

The interactions of amyloid proteins with membranes have been subject to many experimental and computational studies, as these interactions contribute in part to neurodegenerative diseases. In this review, we report on recent simulations that have focused on the adsorption and insertion modes of amy...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuong H., Derreumaux, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609340/
https://www.ncbi.nlm.nih.gov/pubmed/37894559
http://dx.doi.org/10.3390/molecules28207080
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author Nguyen, Phuong H.
Derreumaux, Philippe
author_facet Nguyen, Phuong H.
Derreumaux, Philippe
author_sort Nguyen, Phuong H.
collection PubMed
description The interactions of amyloid proteins with membranes have been subject to many experimental and computational studies, as these interactions contribute in part to neurodegenerative diseases. In this review, we report on recent simulations that have focused on the adsorption and insertion modes of amyloid-β and tau proteins in membranes. The atomistic-resolution characterization of the conformational changes of these amyloid proteins upon lipid cell membrane and free lipid interactions is of interest to rationally design drugs targeting transient oligomers in Alzheimer’s disease.
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spelling pubmed-106093402023-10-28 Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease Nguyen, Phuong H. Derreumaux, Philippe Molecules Review The interactions of amyloid proteins with membranes have been subject to many experimental and computational studies, as these interactions contribute in part to neurodegenerative diseases. In this review, we report on recent simulations that have focused on the adsorption and insertion modes of amyloid-β and tau proteins in membranes. The atomistic-resolution characterization of the conformational changes of these amyloid proteins upon lipid cell membrane and free lipid interactions is of interest to rationally design drugs targeting transient oligomers in Alzheimer’s disease. MDPI 2023-10-13 /pmc/articles/PMC10609340/ /pubmed/37894559 http://dx.doi.org/10.3390/molecules28207080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Phuong H.
Derreumaux, Philippe
Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title_full Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title_fullStr Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title_full_unstemmed Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title_short Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
title_sort recent computational advances regarding amyloid-β and tau membrane interactions in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609340/
https://www.ncbi.nlm.nih.gov/pubmed/37894559
http://dx.doi.org/10.3390/molecules28207080
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