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Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors

Elongated ellipsoidal liquid crystal microdroplet reorientation dynamics are discussed in this paper for biosensor applications. To investigate the effect of elongated droplets on nematic liquid crystal droplet biosensors, we simulated a model of a liquid crystal droplet using ellipse geometry. Dire...

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Autores principales: Shadkami, Reza, Chan, Philip K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609392/
https://www.ncbi.nlm.nih.gov/pubmed/37893268
http://dx.doi.org/10.3390/mi14101831
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author Shadkami, Reza
Chan, Philip K.
author_facet Shadkami, Reza
Chan, Philip K.
author_sort Shadkami, Reza
collection PubMed
description Elongated ellipsoidal liquid crystal microdroplet reorientation dynamics are discussed in this paper for biosensor applications. To investigate the effect of elongated droplets on nematic liquid crystal droplet biosensors, we simulated a model of a liquid crystal droplet using ellipse geometry. Director reorientation is examined in relation to the elongated droplet shape. In addition, we examined aspect ratio as a factor affecting biosensor response time in relation to surface viscosity and anchoring energy. Finally, the findings suggest that the aspect ratio should be taken into account when designing biosensors. These results can be used to develop more effective biosensors for a variety of applications. This model then predicts the director reorientation angle, which is dependent on the anchoring energy and surface viscosity. This model further suggests that both surface viscosity and homeotropic anchoring energy play an important role when it comes to the director reorientation angle. We developed and applied a nonlinear unsteady-state mathematical model utilizing torque balance and Frank free energy according to the Leslie–Ericksen continuum theory for simulating elongated nematic liquid crystal biosensor droplets with aqueous interfaces. Using the Euler–Lagrange equation, a transient liquid crystal–aqueous interface realignment is modeled by changing the easy axis when surfactant molecules are added to the interface. The realignment at the surface of the droplet is assumed to be driven by the effect of the surfactant, which causes an anchoring transition. According to the results, the response time of the biosensor depends on the aspect ratio. Therefore, the elongation has the potential to control biosensing response time. The result of our study provides a better understanding of director reorientation in elongated liquid crystal droplets in biosensing applications through the numerical results which are presented in this paper.
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spelling pubmed-106093922023-10-28 Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors Shadkami, Reza Chan, Philip K. Micromachines (Basel) Article Elongated ellipsoidal liquid crystal microdroplet reorientation dynamics are discussed in this paper for biosensor applications. To investigate the effect of elongated droplets on nematic liquid crystal droplet biosensors, we simulated a model of a liquid crystal droplet using ellipse geometry. Director reorientation is examined in relation to the elongated droplet shape. In addition, we examined aspect ratio as a factor affecting biosensor response time in relation to surface viscosity and anchoring energy. Finally, the findings suggest that the aspect ratio should be taken into account when designing biosensors. These results can be used to develop more effective biosensors for a variety of applications. This model then predicts the director reorientation angle, which is dependent on the anchoring energy and surface viscosity. This model further suggests that both surface viscosity and homeotropic anchoring energy play an important role when it comes to the director reorientation angle. We developed and applied a nonlinear unsteady-state mathematical model utilizing torque balance and Frank free energy according to the Leslie–Ericksen continuum theory for simulating elongated nematic liquid crystal biosensor droplets with aqueous interfaces. Using the Euler–Lagrange equation, a transient liquid crystal–aqueous interface realignment is modeled by changing the easy axis when surfactant molecules are added to the interface. The realignment at the surface of the droplet is assumed to be driven by the effect of the surfactant, which causes an anchoring transition. According to the results, the response time of the biosensor depends on the aspect ratio. Therefore, the elongation has the potential to control biosensing response time. The result of our study provides a better understanding of director reorientation in elongated liquid crystal droplets in biosensing applications through the numerical results which are presented in this paper. MDPI 2023-09-26 /pmc/articles/PMC10609392/ /pubmed/37893268 http://dx.doi.org/10.3390/mi14101831 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shadkami, Reza
Chan, Philip K.
Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title_full Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title_fullStr Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title_full_unstemmed Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title_short Computational Analysis on the Performance of Elongated Liquid Crystal Biosensors
title_sort computational analysis on the performance of elongated liquid crystal biosensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609392/
https://www.ncbi.nlm.nih.gov/pubmed/37893268
http://dx.doi.org/10.3390/mi14101831
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