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Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals
Background: Tracking the migration pathways of living cells after their introduction into a patient’s body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609482/ https://www.ncbi.nlm.nih.gov/pubmed/37894647 http://dx.doi.org/10.3390/molecules28207169 |
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author | Astrelina, Tatiana A. Brunchukov, Vitaliy A. Kodina, Galina E. Bubenshchikov, Viktor B. Larenkov, Anton A. Lunev, Aleksandr S. Petrosova, Kristina A. Rastorgueva, Anna A. Kobzeva, Irina V. Usupzhanova, Daria Y. Nikitina, Victoria A. Malsagova, Kristina A. Kulikova, Ludmila I. Samoilov, Alexander S. Pustovoyt, Vasiliy I. |
author_facet | Astrelina, Tatiana A. Brunchukov, Vitaliy A. Kodina, Galina E. Bubenshchikov, Viktor B. Larenkov, Anton A. Lunev, Aleksandr S. Petrosova, Kristina A. Rastorgueva, Anna A. Kobzeva, Irina V. Usupzhanova, Daria Y. Nikitina, Victoria A. Malsagova, Kristina A. Kulikova, Ludmila I. Samoilov, Alexander S. Pustovoyt, Vasiliy I. |
author_sort | Astrelina, Tatiana A. |
collection | PubMed |
description | Background: Tracking the migration pathways of living cells after their introduction into a patient’s body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain open. Methods: Forty-nine laboratory animals were used in the study. Modeling of local radiation injuries was carried out, and the dynamics of the distribution of mesenchymal stromal cells labeled with [(89)Zr]Zr-oxine in the rat body were studied. Results: the obtained results of the labelled cell distribution allow us to assume that this procedure could be useful for visualization of local radiation injury using positron emission tomography. However, further research is needed to confirm this assumption. Conclusions: intravenous injection leads to the initial accumulation of cells in the lungs and their subsequent redistribution to the liver, spleen, and kidneys. When locally injected into tissues, mesenchymal stromal cells are not distributed systemically in significant quantities. |
format | Online Article Text |
id | pubmed-10609482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106094822023-10-28 Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals Astrelina, Tatiana A. Brunchukov, Vitaliy A. Kodina, Galina E. Bubenshchikov, Viktor B. Larenkov, Anton A. Lunev, Aleksandr S. Petrosova, Kristina A. Rastorgueva, Anna A. Kobzeva, Irina V. Usupzhanova, Daria Y. Nikitina, Victoria A. Malsagova, Kristina A. Kulikova, Ludmila I. Samoilov, Alexander S. Pustovoyt, Vasiliy I. Molecules Article Background: Tracking the migration pathways of living cells after their introduction into a patient’s body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain open. Methods: Forty-nine laboratory animals were used in the study. Modeling of local radiation injuries was carried out, and the dynamics of the distribution of mesenchymal stromal cells labeled with [(89)Zr]Zr-oxine in the rat body were studied. Results: the obtained results of the labelled cell distribution allow us to assume that this procedure could be useful for visualization of local radiation injury using positron emission tomography. However, further research is needed to confirm this assumption. Conclusions: intravenous injection leads to the initial accumulation of cells in the lungs and their subsequent redistribution to the liver, spleen, and kidneys. When locally injected into tissues, mesenchymal stromal cells are not distributed systemically in significant quantities. MDPI 2023-10-19 /pmc/articles/PMC10609482/ /pubmed/37894647 http://dx.doi.org/10.3390/molecules28207169 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Astrelina, Tatiana A. Brunchukov, Vitaliy A. Kodina, Galina E. Bubenshchikov, Viktor B. Larenkov, Anton A. Lunev, Aleksandr S. Petrosova, Kristina A. Rastorgueva, Anna A. Kobzeva, Irina V. Usupzhanova, Daria Y. Nikitina, Victoria A. Malsagova, Kristina A. Kulikova, Ludmila I. Samoilov, Alexander S. Pustovoyt, Vasiliy I. Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title | Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title_full | Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title_fullStr | Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title_full_unstemmed | Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title_short | Biodistribution of Mesenchymal Stromal Cells Labeled with [(89)Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals |
title_sort | biodistribution of mesenchymal stromal cells labeled with [(89)zr]zr-oxine in local radiation injuries in laboratory animals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609482/ https://www.ncbi.nlm.nih.gov/pubmed/37894647 http://dx.doi.org/10.3390/molecules28207169 |
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