Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle

Selective dehydrogenative silylation is one of the most valuable tools for synthesizing organosilicon compounds. In this study, a regio- and stereoselective ruthenium-catalyzed dehydrogenative intermolecular silylation was firstly developed to access (E)-alkenyl silyl-ether derivatives and silyl-eth...

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Autores principales: Huang, Ziwei, Lin, Qiao, Li, Jiefang, Xu, Shanshan, Lv, Shaohuan, Xie, Feng, Wang, Jun, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609488/
https://www.ncbi.nlm.nih.gov/pubmed/37894665
http://dx.doi.org/10.3390/molecules28207186
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author Huang, Ziwei
Lin, Qiao
Li, Jiefang
Xu, Shanshan
Lv, Shaohuan
Xie, Feng
Wang, Jun
Li, Bin
author_facet Huang, Ziwei
Lin, Qiao
Li, Jiefang
Xu, Shanshan
Lv, Shaohuan
Xie, Feng
Wang, Jun
Li, Bin
author_sort Huang, Ziwei
collection PubMed
description Selective dehydrogenative silylation is one of the most valuable tools for synthesizing organosilicon compounds. In this study, a regio- and stereoselective ruthenium-catalyzed dehydrogenative intermolecular silylation was firstly developed to access (E)-alkenyl silyl-ether derivatives and silyl-ether heterocycles with good functional group tolerance. Furthermore, two pathways for RuH(2)(CO)(PPh(3))(3)/NBE-catalyzed dehydrogenative intermolecular silylation of alcohols and alkenes as well as intermolecular silylation of naphthol derivatives were investigated with H(2)SiEt(2) as the hydrosilane reagent.
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spelling pubmed-106094882023-10-28 Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle Huang, Ziwei Lin, Qiao Li, Jiefang Xu, Shanshan Lv, Shaohuan Xie, Feng Wang, Jun Li, Bin Molecules Article Selective dehydrogenative silylation is one of the most valuable tools for synthesizing organosilicon compounds. In this study, a regio- and stereoselective ruthenium-catalyzed dehydrogenative intermolecular silylation was firstly developed to access (E)-alkenyl silyl-ether derivatives and silyl-ether heterocycles with good functional group tolerance. Furthermore, two pathways for RuH(2)(CO)(PPh(3))(3)/NBE-catalyzed dehydrogenative intermolecular silylation of alcohols and alkenes as well as intermolecular silylation of naphthol derivatives were investigated with H(2)SiEt(2) as the hydrosilane reagent. MDPI 2023-10-20 /pmc/articles/PMC10609488/ /pubmed/37894665 http://dx.doi.org/10.3390/molecules28207186 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Ziwei
Lin, Qiao
Li, Jiefang
Xu, Shanshan
Lv, Shaohuan
Xie, Feng
Wang, Jun
Li, Bin
Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title_full Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title_fullStr Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title_full_unstemmed Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title_short Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
title_sort ruthenium-catalyzed dehydrogenative intermolecular o-h/si-h/c-h silylation: synthesis of (e)-alkenyl silyl-ether and silyl-ether heterocycle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609488/
https://www.ncbi.nlm.nih.gov/pubmed/37894665
http://dx.doi.org/10.3390/molecules28207186
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