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History of Maturation of Prokaryotic Molybdoenzymes—A Personal View

In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organiza...

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Autor principal: Magalon, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609526/
https://www.ncbi.nlm.nih.gov/pubmed/37894674
http://dx.doi.org/10.3390/molecules28207195
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author Magalon, Axel
author_facet Magalon, Axel
author_sort Magalon, Axel
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description In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organization of these enzymes, which often include additional redox centers, is as diverse as ever, as is their cellular localization. The most notable observation is the involvement of dedicated chaperones assisting with the assembly and acquisition of the metal centers, including Mo/W-bisPGD, one of the largest organic cofactors in nature. This review seeks to provide a new understanding and a unified model of Mo/W enzyme maturation.
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spelling pubmed-106095262023-10-28 History of Maturation of Prokaryotic Molybdoenzymes—A Personal View Magalon, Axel Molecules Review In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organization of these enzymes, which often include additional redox centers, is as diverse as ever, as is their cellular localization. The most notable observation is the involvement of dedicated chaperones assisting with the assembly and acquisition of the metal centers, including Mo/W-bisPGD, one of the largest organic cofactors in nature. This review seeks to provide a new understanding and a unified model of Mo/W enzyme maturation. MDPI 2023-10-20 /pmc/articles/PMC10609526/ /pubmed/37894674 http://dx.doi.org/10.3390/molecules28207195 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Magalon, Axel
History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title_full History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title_fullStr History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title_full_unstemmed History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title_short History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
title_sort history of maturation of prokaryotic molybdoenzymes—a personal view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609526/
https://www.ncbi.nlm.nih.gov/pubmed/37894674
http://dx.doi.org/10.3390/molecules28207195
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