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History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organiza...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609526/ https://www.ncbi.nlm.nih.gov/pubmed/37894674 http://dx.doi.org/10.3390/molecules28207195 |
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author | Magalon, Axel |
author_facet | Magalon, Axel |
author_sort | Magalon, Axel |
collection | PubMed |
description | In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organization of these enzymes, which often include additional redox centers, is as diverse as ever, as is their cellular localization. The most notable observation is the involvement of dedicated chaperones assisting with the assembly and acquisition of the metal centers, including Mo/W-bisPGD, one of the largest organic cofactors in nature. This review seeks to provide a new understanding and a unified model of Mo/W enzyme maturation. |
format | Online Article Text |
id | pubmed-10609526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106095262023-10-28 History of Maturation of Prokaryotic Molybdoenzymes—A Personal View Magalon, Axel Molecules Review In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organization of these enzymes, which often include additional redox centers, is as diverse as ever, as is their cellular localization. The most notable observation is the involvement of dedicated chaperones assisting with the assembly and acquisition of the metal centers, including Mo/W-bisPGD, one of the largest organic cofactors in nature. This review seeks to provide a new understanding and a unified model of Mo/W enzyme maturation. MDPI 2023-10-20 /pmc/articles/PMC10609526/ /pubmed/37894674 http://dx.doi.org/10.3390/molecules28207195 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Magalon, Axel History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title | History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title_full | History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title_fullStr | History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title_full_unstemmed | History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title_short | History of Maturation of Prokaryotic Molybdoenzymes—A Personal View |
title_sort | history of maturation of prokaryotic molybdoenzymes—a personal view |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609526/ https://www.ncbi.nlm.nih.gov/pubmed/37894674 http://dx.doi.org/10.3390/molecules28207195 |
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