Diastereoselective Cascade Cyclization of Diazoimides with Alkylidene Pyrazolones for Preparation of Pyrazole-Fused Oxa-Bridged Oxazocines

Under the catalysis of Rh(2)(OAc)(4) (10 mol%) and binapbisphosphine ligand (±)-L3 (20 mol%) in DCE at 80 °C, the cascade cyclization of diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-fused oxa-bridged oxazocines in reasonable chemical yields. T...

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Detalles Bibliográficos
Autores principales: Wang, Kuo, Zhang, Yue, Cai, Lu-Yu, Song, Xiu-Qing, Wang, Chen, Zhang, Jia-Rui, Pan, Yi-Fan, Zhao, Hong-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609588/
https://www.ncbi.nlm.nih.gov/pubmed/37894500
http://dx.doi.org/10.3390/molecules28207021
Descripción
Sumario:Under the catalysis of Rh(2)(OAc)(4) (10 mol%) and binapbisphosphine ligand (±)-L3 (20 mol%) in DCE at 80 °C, the cascade cyclization of diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-fused oxa-bridged oxazocines in reasonable chemical yields. The chemical structure and relative configuration of title products were firmly identified by X-ray diffraction analysis.

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