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Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609600/ https://www.ncbi.nlm.nih.gov/pubmed/37892403 http://dx.doi.org/10.3390/nu15204327 |
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author | Di Lauro, Manuela Guerriero, Cristina Cornali, Kevin Albanese, Maria Costacurta, Micaela Mercuri, Nicola Biagio Di Daniele, Nicola Noce, Annalisa |
author_facet | Di Lauro, Manuela Guerriero, Cristina Cornali, Kevin Albanese, Maria Costacurta, Micaela Mercuri, Nicola Biagio Di Daniele, Nicola Noce, Annalisa |
author_sort | Di Lauro, Manuela |
collection | PubMed |
description | In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis. |
format | Online Article Text |
id | pubmed-10609600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106096002023-10-28 Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases Di Lauro, Manuela Guerriero, Cristina Cornali, Kevin Albanese, Maria Costacurta, Micaela Mercuri, Nicola Biagio Di Daniele, Nicola Noce, Annalisa Nutrients Review In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis. MDPI 2023-10-11 /pmc/articles/PMC10609600/ /pubmed/37892403 http://dx.doi.org/10.3390/nu15204327 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Lauro, Manuela Guerriero, Cristina Cornali, Kevin Albanese, Maria Costacurta, Micaela Mercuri, Nicola Biagio Di Daniele, Nicola Noce, Annalisa Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title | Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title_full | Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title_fullStr | Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title_full_unstemmed | Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title_short | Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases |
title_sort | linking migraine to gut dysbiosis and chronic non-communicable diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609600/ https://www.ncbi.nlm.nih.gov/pubmed/37892403 http://dx.doi.org/10.3390/nu15204327 |
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