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Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be...

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Autores principales: Di Lauro, Manuela, Guerriero, Cristina, Cornali, Kevin, Albanese, Maria, Costacurta, Micaela, Mercuri, Nicola Biagio, Di Daniele, Nicola, Noce, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609600/
https://www.ncbi.nlm.nih.gov/pubmed/37892403
http://dx.doi.org/10.3390/nu15204327
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author Di Lauro, Manuela
Guerriero, Cristina
Cornali, Kevin
Albanese, Maria
Costacurta, Micaela
Mercuri, Nicola Biagio
Di Daniele, Nicola
Noce, Annalisa
author_facet Di Lauro, Manuela
Guerriero, Cristina
Cornali, Kevin
Albanese, Maria
Costacurta, Micaela
Mercuri, Nicola Biagio
Di Daniele, Nicola
Noce, Annalisa
author_sort Di Lauro, Manuela
collection PubMed
description In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis.
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spelling pubmed-106096002023-10-28 Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases Di Lauro, Manuela Guerriero, Cristina Cornali, Kevin Albanese, Maria Costacurta, Micaela Mercuri, Nicola Biagio Di Daniele, Nicola Noce, Annalisa Nutrients Review In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis. MDPI 2023-10-11 /pmc/articles/PMC10609600/ /pubmed/37892403 http://dx.doi.org/10.3390/nu15204327 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Lauro, Manuela
Guerriero, Cristina
Cornali, Kevin
Albanese, Maria
Costacurta, Micaela
Mercuri, Nicola Biagio
Di Daniele, Nicola
Noce, Annalisa
Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title_full Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title_fullStr Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title_full_unstemmed Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title_short Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
title_sort linking migraine to gut dysbiosis and chronic non-communicable diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609600/
https://www.ncbi.nlm.nih.gov/pubmed/37892403
http://dx.doi.org/10.3390/nu15204327
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