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Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments

Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients’ intestines to restore gut–immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bo...

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Autores principales: Martinelli, Serena, Nannini, Giulia, Cianchi, Fabio, Staderini, Fabio, Coratti, Francesco, Amedei, Amedeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609601/
https://www.ncbi.nlm.nih.gov/pubmed/37894065
http://dx.doi.org/10.3390/microorganisms11102407
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author Martinelli, Serena
Nannini, Giulia
Cianchi, Fabio
Staderini, Fabio
Coratti, Francesco
Amedei, Amedeo
author_facet Martinelli, Serena
Nannini, Giulia
Cianchi, Fabio
Staderini, Fabio
Coratti, Francesco
Amedei, Amedeo
author_sort Martinelli, Serena
collection PubMed
description Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients’ intestines to restore gut–immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome—and especially Clostridium difficile infection (currently the only used as clinical treatment)—recent research has suggested that it may also become a potential treatment for gynecological disorders, including endometriosis and polycystic ovary syndrome (PCOS). On the contrary, vaginal microbiota transplantation (VMT) is a newer and less commonly used procedure than the FMT approach, and its potential applications are still being explored. It involves direct grafting of the entire vaginal microbiota of healthy women into the vaginal tract of patients to easily rebuild the local microbiota environment, restoring vaginal eubiosis and relieving symptoms. Like FMT, VMT is thought to have potential in treating different microbiota-related conditions. In fact, many gynecological disorders, such as bacterial vaginosis and vulvovaginal candidiasis, are thought to be caused by an imbalance in the vaginal microbiota. In this review, we will summarize the development, current challenges, and future perspectives of microbiota transplant, with the aim of exploring new strategies for its employment as a promising avenue for treating a broad range of gynecological diseases.
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spelling pubmed-106096012023-10-28 Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments Martinelli, Serena Nannini, Giulia Cianchi, Fabio Staderini, Fabio Coratti, Francesco Amedei, Amedeo Microorganisms Review Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients’ intestines to restore gut–immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome—and especially Clostridium difficile infection (currently the only used as clinical treatment)—recent research has suggested that it may also become a potential treatment for gynecological disorders, including endometriosis and polycystic ovary syndrome (PCOS). On the contrary, vaginal microbiota transplantation (VMT) is a newer and less commonly used procedure than the FMT approach, and its potential applications are still being explored. It involves direct grafting of the entire vaginal microbiota of healthy women into the vaginal tract of patients to easily rebuild the local microbiota environment, restoring vaginal eubiosis and relieving symptoms. Like FMT, VMT is thought to have potential in treating different microbiota-related conditions. In fact, many gynecological disorders, such as bacterial vaginosis and vulvovaginal candidiasis, are thought to be caused by an imbalance in the vaginal microbiota. In this review, we will summarize the development, current challenges, and future perspectives of microbiota transplant, with the aim of exploring new strategies for its employment as a promising avenue for treating a broad range of gynecological diseases. MDPI 2023-09-27 /pmc/articles/PMC10609601/ /pubmed/37894065 http://dx.doi.org/10.3390/microorganisms11102407 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martinelli, Serena
Nannini, Giulia
Cianchi, Fabio
Staderini, Fabio
Coratti, Francesco
Amedei, Amedeo
Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title_full Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title_fullStr Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title_full_unstemmed Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title_short Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments
title_sort microbiota transplant and gynecological disorders: the bridge between present and future treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609601/
https://www.ncbi.nlm.nih.gov/pubmed/37894065
http://dx.doi.org/10.3390/microorganisms11102407
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