Development of an HPLC-MS/MS Method for Chiral Separation and Quantitation of (R)- and (S)-Salbutamol and Their Sulfoconjugated Metabolites in Urine to Investigate Stereoselective Sulfonation

The aim of this study was to develop and optimize a chiral HPLC-MS/MS method for quantitative analysis of (R)-/(S)-salbutamol and (R)-/(S)-salbutamol-4′-O-sulfate in human urine to allow for bioanalytical quantitation of the targeted analytes and investigations of stereoselectivity in the sulfonatio...

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Detalles Bibliográficos
Autores principales: Harps, Lukas Corbinian, Jendretzki, Annika Lisa, Wolf, Clemens Alexander, Girreser, Ulrich, Wolber, Gerhard, Parr, Maria Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609612/
https://www.ncbi.nlm.nih.gov/pubmed/37894685
http://dx.doi.org/10.3390/molecules28207206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609612/
https://www.ncbi.nlm.nih.gov/pubmed/37894685
http://dx.doi.org/10.3390/molecules28207206

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