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Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks

Fenpyroximate is an efficient, broad-spectrum phenoxypyrazole acaricide which is used for controlling various mites. In this study, we measured the levels of terminal fenpyroximate residues in citrus fruits, and estimated the dietary intake risks posed by fenpyroximate. To this end, a QuEChERS analy...

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Autores principales: Sun, Ruiqing, Cao, Junli, Li, Jindong, Qi, Yanli, Qin, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609617/
https://www.ncbi.nlm.nih.gov/pubmed/37894602
http://dx.doi.org/10.3390/molecules28207123
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author Sun, Ruiqing
Cao, Junli
Li, Jindong
Qi, Yanli
Qin, Shu
author_facet Sun, Ruiqing
Cao, Junli
Li, Jindong
Qi, Yanli
Qin, Shu
author_sort Sun, Ruiqing
collection PubMed
description Fenpyroximate is an efficient, broad-spectrum phenoxypyrazole acaricide which is used for controlling various mites. In this study, we measured the levels of terminal fenpyroximate residues in citrus fruits, and estimated the dietary intake risks posed by fenpyroximate. To this end, a QuEChERS analytical method was used in combination with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) to determine the residual levels of fenpyroximate and its Z-isomer (Z-fenpyroximate) in citrus fruits collected from 12 fields under good agricultural practices (GAPs). The average recoveries of fenpyroximate in whole fruits and citrus flesh were 104–110% and 92–109%, respectively, with corresponding RSDs of 1–4% and 1–3%. The average recoveries of Z-fenpyroximate were 104–113% and 90–91%, respectively, with RSDs of 1–2% in both cases. Each limit of quantification (LOQ) was 0.01 mg kg(−1). Fifteen days after application with 56 mg kg(−1), the terminal residues of fenpyroximate in whole fruits and citrus flesh were <0.010–0.18 mg kg(−1) and <0.010–0.063 mg kg(−1), respectively; the corresponding values for total fenpyroximate (the sum of fenpyroximate and Z-fenpyroximate) were <0.020–0.19 and <0.020–0.053 mg kg(−1). The levels of terminal fenpyroximate residues in citrus fruit were less than the maximum residue limits (MRLs) specified in all the existing international standards. In addition, the risk quotients RQ(c) and RQ(a) were both less than 100%, indicating that the long-term and short-term dietary intake risks posed to Chinese consumers by fenpyroximate in citrus fruit are both acceptable after a 15-day harvest interval.
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spelling pubmed-106096172023-10-28 Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks Sun, Ruiqing Cao, Junli Li, Jindong Qi, Yanli Qin, Shu Molecules Article Fenpyroximate is an efficient, broad-spectrum phenoxypyrazole acaricide which is used for controlling various mites. In this study, we measured the levels of terminal fenpyroximate residues in citrus fruits, and estimated the dietary intake risks posed by fenpyroximate. To this end, a QuEChERS analytical method was used in combination with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) to determine the residual levels of fenpyroximate and its Z-isomer (Z-fenpyroximate) in citrus fruits collected from 12 fields under good agricultural practices (GAPs). The average recoveries of fenpyroximate in whole fruits and citrus flesh were 104–110% and 92–109%, respectively, with corresponding RSDs of 1–4% and 1–3%. The average recoveries of Z-fenpyroximate were 104–113% and 90–91%, respectively, with RSDs of 1–2% in both cases. Each limit of quantification (LOQ) was 0.01 mg kg(−1). Fifteen days after application with 56 mg kg(−1), the terminal residues of fenpyroximate in whole fruits and citrus flesh were <0.010–0.18 mg kg(−1) and <0.010–0.063 mg kg(−1), respectively; the corresponding values for total fenpyroximate (the sum of fenpyroximate and Z-fenpyroximate) were <0.020–0.19 and <0.020–0.053 mg kg(−1). The levels of terminal fenpyroximate residues in citrus fruit were less than the maximum residue limits (MRLs) specified in all the existing international standards. In addition, the risk quotients RQ(c) and RQ(a) were both less than 100%, indicating that the long-term and short-term dietary intake risks posed to Chinese consumers by fenpyroximate in citrus fruit are both acceptable after a 15-day harvest interval. MDPI 2023-10-17 /pmc/articles/PMC10609617/ /pubmed/37894602 http://dx.doi.org/10.3390/molecules28207123 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Ruiqing
Cao, Junli
Li, Jindong
Qi, Yanli
Qin, Shu
Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title_full Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title_fullStr Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title_full_unstemmed Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title_short Measuring the Residual Levels of Fenpyroximate and Its Z-Isomer in Citrus Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Assessing the Related Dietary Intake Risks
title_sort measuring the residual levels of fenpyroximate and its z-isomer in citrus using ultra-high-performance liquid chromatography–tandem mass spectrometry and assessing the related dietary intake risks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609617/
https://www.ncbi.nlm.nih.gov/pubmed/37894602
http://dx.doi.org/10.3390/molecules28207123
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