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Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Free drug concentrations are generally considered the pharmacologically active moiety and are important for cellular diffusion and distribution. Pregnancy-related changes in plasma protein binding and blood partitioning are due to decreases in plasma albumin, alpha-1-acid glycoprotein, and haematocr...

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Detalles Bibliográficos
Autores principales:	Coppola, Paola, Butler, Andrew, Cole, Susan, Kerwash, Essam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609738/ https://www.ncbi.nlm.nih.gov/pubmed/37896215 http://dx.doi.org/10.3390/pharmaceutics15102455

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