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Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy

Spontaneous HBsAg seroclearance has been mainly studied in populations from Asia, Australia, the Pacific Islands, and Polynesia. For the first time, we evaluated the spontaneous HBsAg seroclearance and its possible associated factors and the risk of disease progression in HBeAg-negative patients wit...

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Autores principales: Barone, Michele, Iannone, Andrea, Mezzapesa, Martino, Milella, Michele, Di Gennaro, Francesco, Niro, Grazia, Cotugno, Rosa, Cozzolongo, Raffaele, Mennea, Giuseppe, Rendina, Maria, Di Leo, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609832/
https://www.ncbi.nlm.nih.gov/pubmed/37887714
http://dx.doi.org/10.3390/pathogens12101198
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author Barone, Michele
Iannone, Andrea
Mezzapesa, Martino
Milella, Michele
Di Gennaro, Francesco
Niro, Grazia
Cotugno, Rosa
Cozzolongo, Raffaele
Mennea, Giuseppe
Rendina, Maria
Di Leo, Alfredo
author_facet Barone, Michele
Iannone, Andrea
Mezzapesa, Martino
Milella, Michele
Di Gennaro, Francesco
Niro, Grazia
Cotugno, Rosa
Cozzolongo, Raffaele
Mennea, Giuseppe
Rendina, Maria
Di Leo, Alfredo
author_sort Barone, Michele
collection PubMed
description Spontaneous HBsAg seroclearance has been mainly studied in populations from Asia, Australia, the Pacific Islands, and Polynesia. For the first time, we evaluated the spontaneous HBsAg seroclearance and its possible associated factors and the risk of disease progression in HBeAg-negative patients with inactive infection all coming from the same region in South Italy. In this multicenter retrospective study, 146 patients were selected after 18 months of observation and followed for a median of 82 months (IQR 60–107). For our analyses, they were divided into three groups based on their HBsAg levels: <100 IU/mL, 100–1000 IU/mL, and >1000 IU/mL. Crude and adjusted hazard ratios (HRs) for HBsAg seroclearance were determined. During the follow-up period, three patients (2.0%) showed a disease progression with an increased liver stiffness, whereas 17 (11.6%) cleared the HBsAg. Patients with HBsAg levels <100 IU/mL had the highest probability of HBsAg seroclearance compared to the other two groups (p = 0.009). In the multivariate analysis, the HBsAg level <100 IU/mL was the only parameter independently associated with HBsAg seroclearance (adjusted HR = 3.53; CI 1.29–9.69; p = 0.01). In patients with chronic HBV inactive infection, HBsAg levels <100 IU/mL predicted the highest probability of HBsAg seroclearance.
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spelling pubmed-106098322023-10-28 Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy Barone, Michele Iannone, Andrea Mezzapesa, Martino Milella, Michele Di Gennaro, Francesco Niro, Grazia Cotugno, Rosa Cozzolongo, Raffaele Mennea, Giuseppe Rendina, Maria Di Leo, Alfredo Pathogens Communication Spontaneous HBsAg seroclearance has been mainly studied in populations from Asia, Australia, the Pacific Islands, and Polynesia. For the first time, we evaluated the spontaneous HBsAg seroclearance and its possible associated factors and the risk of disease progression in HBeAg-negative patients with inactive infection all coming from the same region in South Italy. In this multicenter retrospective study, 146 patients were selected after 18 months of observation and followed for a median of 82 months (IQR 60–107). For our analyses, they were divided into three groups based on their HBsAg levels: <100 IU/mL, 100–1000 IU/mL, and >1000 IU/mL. Crude and adjusted hazard ratios (HRs) for HBsAg seroclearance were determined. During the follow-up period, three patients (2.0%) showed a disease progression with an increased liver stiffness, whereas 17 (11.6%) cleared the HBsAg. Patients with HBsAg levels <100 IU/mL had the highest probability of HBsAg seroclearance compared to the other two groups (p = 0.009). In the multivariate analysis, the HBsAg level <100 IU/mL was the only parameter independently associated with HBsAg seroclearance (adjusted HR = 3.53; CI 1.29–9.69; p = 0.01). In patients with chronic HBV inactive infection, HBsAg levels <100 IU/mL predicted the highest probability of HBsAg seroclearance. MDPI 2023-09-26 /pmc/articles/PMC10609832/ /pubmed/37887714 http://dx.doi.org/10.3390/pathogens12101198 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Barone, Michele
Iannone, Andrea
Mezzapesa, Martino
Milella, Michele
Di Gennaro, Francesco
Niro, Grazia
Cotugno, Rosa
Cozzolongo, Raffaele
Mennea, Giuseppe
Rendina, Maria
Di Leo, Alfredo
Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title_full Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title_fullStr Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title_full_unstemmed Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title_short Natural History and Hepatitis B Virus Surface Antigen (HBsAg) Spontaneous Seroclearance in Hepatitis B Virus e-Antigen (HBeAg)-Negative Patients with Inactive Chronic Infection: A Multicenter Regional Study from South Italy
title_sort natural history and hepatitis b virus surface antigen (hbsag) spontaneous seroclearance in hepatitis b virus e-antigen (hbeag)-negative patients with inactive chronic infection: a multicenter regional study from south italy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609832/
https://www.ncbi.nlm.nih.gov/pubmed/37887714
http://dx.doi.org/10.3390/pathogens12101198
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