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Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System

Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxi...

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Autores principales: Khattak, Muzna Ali, Iqbal, Zafar, Nasir, Fazli, Neau, Steven H., Khan, Sumaira Irum, Hidayatullah, Talaya, Pervez, Sadia, Sakhi, Mirina, Zainab, Syeda Rabqa, Gohar, Shazma, Alasmari, Fawaz, Rahman, Altafur, Maryam, Gul e, Tahir, Arbab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609841/
https://www.ncbi.nlm.nih.gov/pubmed/37896131
http://dx.doi.org/10.3390/pharmaceutics15102373
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author Khattak, Muzna Ali
Iqbal, Zafar
Nasir, Fazli
Neau, Steven H.
Khan, Sumaira Irum
Hidayatullah, Talaya
Pervez, Sadia
Sakhi, Mirina
Zainab, Syeda Rabqa
Gohar, Shazma
Alasmari, Fawaz
Rahman, Altafur
Maryam, Gul e
Tahir, Arbab
author_facet Khattak, Muzna Ali
Iqbal, Zafar
Nasir, Fazli
Neau, Steven H.
Khan, Sumaira Irum
Hidayatullah, Talaya
Pervez, Sadia
Sakhi, Mirina
Zainab, Syeda Rabqa
Gohar, Shazma
Alasmari, Fawaz
Rahman, Altafur
Maryam, Gul e
Tahir, Arbab
author_sort Khattak, Muzna Ali
collection PubMed
description Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxifen-loaded Eudragit nanoparticles by identifying the significant process variables using the nanoprecipitation method. The process variables (amount of drug, polymer, and surfactant) were altered to analyze the influence on particle size (PS), % encapsulation efficiency (EE). The results showed that the drug and polymer individually as well as collectively have an impact on PS, while the surfactant has no impact on the PS. The %EE was influenced by the surfactant individually and in interaction with the drug. The linear regression model was endorsed to fit the data showing high R(2) values (PS, 0.9146, %EE, 0.9070) and low p values (PS, 0.0004, EE, 0.0005). The PS and EE were confirmed to be 178 nm and 90%, respectively. The nanoparticles were of spherical shape, as confirmed by SEM and TEM. The FTIR confirmed the absence of any incompatibility among the ingredients. The TGA confirmed that the NPs were thermally stable. The in vitro release predicted that the drug release followed Higuchi model.
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spelling pubmed-106098412023-10-28 Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System Khattak, Muzna Ali Iqbal, Zafar Nasir, Fazli Neau, Steven H. Khan, Sumaira Irum Hidayatullah, Talaya Pervez, Sadia Sakhi, Mirina Zainab, Syeda Rabqa Gohar, Shazma Alasmari, Fawaz Rahman, Altafur Maryam, Gul e Tahir, Arbab Pharmaceutics Article Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxifen-loaded Eudragit nanoparticles by identifying the significant process variables using the nanoprecipitation method. The process variables (amount of drug, polymer, and surfactant) were altered to analyze the influence on particle size (PS), % encapsulation efficiency (EE). The results showed that the drug and polymer individually as well as collectively have an impact on PS, while the surfactant has no impact on the PS. The %EE was influenced by the surfactant individually and in interaction with the drug. The linear regression model was endorsed to fit the data showing high R(2) values (PS, 0.9146, %EE, 0.9070) and low p values (PS, 0.0004, EE, 0.0005). The PS and EE were confirmed to be 178 nm and 90%, respectively. The nanoparticles were of spherical shape, as confirmed by SEM and TEM. The FTIR confirmed the absence of any incompatibility among the ingredients. The TGA confirmed that the NPs were thermally stable. The in vitro release predicted that the drug release followed Higuchi model. MDPI 2023-09-22 /pmc/articles/PMC10609841/ /pubmed/37896131 http://dx.doi.org/10.3390/pharmaceutics15102373 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khattak, Muzna Ali
Iqbal, Zafar
Nasir, Fazli
Neau, Steven H.
Khan, Sumaira Irum
Hidayatullah, Talaya
Pervez, Sadia
Sakhi, Mirina
Zainab, Syeda Rabqa
Gohar, Shazma
Alasmari, Fawaz
Rahman, Altafur
Maryam, Gul e
Tahir, Arbab
Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title_full Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title_fullStr Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title_full_unstemmed Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title_short Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
title_sort tamoxifen-loaded eudragit nanoparticles: quality by design approach for optimization of nanoparticles as delivery system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609841/
https://www.ncbi.nlm.nih.gov/pubmed/37896131
http://dx.doi.org/10.3390/pharmaceutics15102373
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