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Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System
Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609841/ https://www.ncbi.nlm.nih.gov/pubmed/37896131 http://dx.doi.org/10.3390/pharmaceutics15102373 |
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author | Khattak, Muzna Ali Iqbal, Zafar Nasir, Fazli Neau, Steven H. Khan, Sumaira Irum Hidayatullah, Talaya Pervez, Sadia Sakhi, Mirina Zainab, Syeda Rabqa Gohar, Shazma Alasmari, Fawaz Rahman, Altafur Maryam, Gul e Tahir, Arbab |
author_facet | Khattak, Muzna Ali Iqbal, Zafar Nasir, Fazli Neau, Steven H. Khan, Sumaira Irum Hidayatullah, Talaya Pervez, Sadia Sakhi, Mirina Zainab, Syeda Rabqa Gohar, Shazma Alasmari, Fawaz Rahman, Altafur Maryam, Gul e Tahir, Arbab |
author_sort | Khattak, Muzna Ali |
collection | PubMed |
description | Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxifen-loaded Eudragit nanoparticles by identifying the significant process variables using the nanoprecipitation method. The process variables (amount of drug, polymer, and surfactant) were altered to analyze the influence on particle size (PS), % encapsulation efficiency (EE). The results showed that the drug and polymer individually as well as collectively have an impact on PS, while the surfactant has no impact on the PS. The %EE was influenced by the surfactant individually and in interaction with the drug. The linear regression model was endorsed to fit the data showing high R(2) values (PS, 0.9146, %EE, 0.9070) and low p values (PS, 0.0004, EE, 0.0005). The PS and EE were confirmed to be 178 nm and 90%, respectively. The nanoparticles were of spherical shape, as confirmed by SEM and TEM. The FTIR confirmed the absence of any incompatibility among the ingredients. The TGA confirmed that the NPs were thermally stable. The in vitro release predicted that the drug release followed Higuchi model. |
format | Online Article Text |
id | pubmed-10609841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106098412023-10-28 Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System Khattak, Muzna Ali Iqbal, Zafar Nasir, Fazli Neau, Steven H. Khan, Sumaira Irum Hidayatullah, Talaya Pervez, Sadia Sakhi, Mirina Zainab, Syeda Rabqa Gohar, Shazma Alasmari, Fawaz Rahman, Altafur Maryam, Gul e Tahir, Arbab Pharmaceutics Article Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxifen-loaded Eudragit nanoparticles by identifying the significant process variables using the nanoprecipitation method. The process variables (amount of drug, polymer, and surfactant) were altered to analyze the influence on particle size (PS), % encapsulation efficiency (EE). The results showed that the drug and polymer individually as well as collectively have an impact on PS, while the surfactant has no impact on the PS. The %EE was influenced by the surfactant individually and in interaction with the drug. The linear regression model was endorsed to fit the data showing high R(2) values (PS, 0.9146, %EE, 0.9070) and low p values (PS, 0.0004, EE, 0.0005). The PS and EE were confirmed to be 178 nm and 90%, respectively. The nanoparticles were of spherical shape, as confirmed by SEM and TEM. The FTIR confirmed the absence of any incompatibility among the ingredients. The TGA confirmed that the NPs were thermally stable. The in vitro release predicted that the drug release followed Higuchi model. MDPI 2023-09-22 /pmc/articles/PMC10609841/ /pubmed/37896131 http://dx.doi.org/10.3390/pharmaceutics15102373 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khattak, Muzna Ali Iqbal, Zafar Nasir, Fazli Neau, Steven H. Khan, Sumaira Irum Hidayatullah, Talaya Pervez, Sadia Sakhi, Mirina Zainab, Syeda Rabqa Gohar, Shazma Alasmari, Fawaz Rahman, Altafur Maryam, Gul e Tahir, Arbab Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title | Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title_full | Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title_fullStr | Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title_full_unstemmed | Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title_short | Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System |
title_sort | tamoxifen-loaded eudragit nanoparticles: quality by design approach for optimization of nanoparticles as delivery system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609841/ https://www.ncbi.nlm.nih.gov/pubmed/37896131 http://dx.doi.org/10.3390/pharmaceutics15102373 |
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