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Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment
Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA is severely constrained by low serum stability and cell membrane permeability. Therefore, improving the delivery efficiency of siRNA for cancer treatment is a research...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609930/ https://www.ncbi.nlm.nih.gov/pubmed/37896243 http://dx.doi.org/10.3390/pharmaceutics15102483 |
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author | Xie, Xiaowei Yue, Tianxiang Gu, Wenting Cheng, WeiYi He, Li Ren, WeiYe Li, Fanzhu Piao, Ji-Gang |
author_facet | Xie, Xiaowei Yue, Tianxiang Gu, Wenting Cheng, WeiYi He, Li Ren, WeiYe Li, Fanzhu Piao, Ji-Gang |
author_sort | Xie, Xiaowei |
collection | PubMed |
description | Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA is severely constrained by low serum stability and cell membrane permeability. Therefore, improving the delivery efficiency of siRNA for cancer treatment is a research hotspot. Recently, mesoporous silica nanoparticles (MSNs) have emerged as bright delivery vehicles for nucleic acid drugs. A comprehensive understanding of the design of MSN-based vectors is crucial for the application of siRNA in cancer therapy. We discuss several surface-functionalized MSNs’ advancements as effective siRNA delivery vehicles in this paper. The advantages of using MSNs for siRNA loading regarding considerations of different shapes, various options for surface functionalization, and customizable pore sizes are highlighted. We discuss the recent investigations into strategies that efficiently improve cellular uptake, facilitate endosomal escape, and promote cargo dissociation from the MSNs for enhanced intracellular siRNA delivery. Also, particular attention was paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes. |
format | Online Article Text |
id | pubmed-10609930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106099302023-10-28 Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment Xie, Xiaowei Yue, Tianxiang Gu, Wenting Cheng, WeiYi He, Li Ren, WeiYe Li, Fanzhu Piao, Ji-Gang Pharmaceutics Review Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA is severely constrained by low serum stability and cell membrane permeability. Therefore, improving the delivery efficiency of siRNA for cancer treatment is a research hotspot. Recently, mesoporous silica nanoparticles (MSNs) have emerged as bright delivery vehicles for nucleic acid drugs. A comprehensive understanding of the design of MSN-based vectors is crucial for the application of siRNA in cancer therapy. We discuss several surface-functionalized MSNs’ advancements as effective siRNA delivery vehicles in this paper. The advantages of using MSNs for siRNA loading regarding considerations of different shapes, various options for surface functionalization, and customizable pore sizes are highlighted. We discuss the recent investigations into strategies that efficiently improve cellular uptake, facilitate endosomal escape, and promote cargo dissociation from the MSNs for enhanced intracellular siRNA delivery. Also, particular attention was paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes. MDPI 2023-10-17 /pmc/articles/PMC10609930/ /pubmed/37896243 http://dx.doi.org/10.3390/pharmaceutics15102483 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xie, Xiaowei Yue, Tianxiang Gu, Wenting Cheng, WeiYi He, Li Ren, WeiYe Li, Fanzhu Piao, Ji-Gang Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title | Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title_full | Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title_fullStr | Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title_full_unstemmed | Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title_short | Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment |
title_sort | recent advances in mesoporous silica nanoparticles delivering sirna for cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609930/ https://www.ncbi.nlm.nih.gov/pubmed/37896243 http://dx.doi.org/10.3390/pharmaceutics15102483 |
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