Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...

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Detalles Bibliográficos
Autores principales: Pagani, Isabel, Ottoboni, Linda, Panina-Bordignon, Paola, Martino, Gianvito, Poli, Guido, Taylor, Sarah, Turnbull, Jeremy E., Yates, Edwin, Vicenzi, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609960/
https://www.ncbi.nlm.nih.gov/pubmed/37895856
http://dx.doi.org/10.3390/ph16101385

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