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Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?

Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the devel...

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Autores principales: Tayal, Rohit, Yasmin, Sabina, Chauhan, Samrat, Singh, Thakur Gurjeet, Saini, Monika, Shorog, Eman, Althubyani, Maryam M., Alsaadi, Baiaan H., Aljohani, Fatimah, Alenazi, Maram A., Abutaily, Sarah A., Ansari, Mohammad Yousuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609986/
https://www.ncbi.nlm.nih.gov/pubmed/37895858
http://dx.doi.org/10.3390/ph16101387
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author Tayal, Rohit
Yasmin, Sabina
Chauhan, Samrat
Singh, Thakur Gurjeet
Saini, Monika
Shorog, Eman
Althubyani, Maryam M.
Alsaadi, Baiaan H.
Aljohani, Fatimah
Alenazi, Maram A.
Abutaily, Sarah A.
Ansari, Mohammad Yousuf
author_facet Tayal, Rohit
Yasmin, Sabina
Chauhan, Samrat
Singh, Thakur Gurjeet
Saini, Monika
Shorog, Eman
Althubyani, Maryam M.
Alsaadi, Baiaan H.
Aljohani, Fatimah
Alenazi, Maram A.
Abutaily, Sarah A.
Ansari, Mohammad Yousuf
author_sort Tayal, Rohit
collection PubMed
description Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the development of other serious health problems, it can have detrimental consequences for patients. This article explores the correlation between persistent proton pump inhibitor (PPI) use and hypertension, a common cardiovascular ailment. While PPIs are beneficial in treating various gastrointestinal problems, their availability without a prescription has resulted in self-medication and long-term use without medical monitoring. Recent findings have revealed a link between long-term PPI usage and increased cardiovascular risks, particularly hypertension. This study investigates the intricate mechanisms underlying PPI’s effects, focusing on potential pathways contributing to hypertension, such as endothelial dysfunction, disruption of nitric oxide bioavailability, vitamin B deficiency, hypocalcemia, and hypomagnesemia. The discussion explains how long-term PPI use can disrupt normal endothelial function, vascular control, and mineral balance, eventually leading to hypertension. The article emphasizes the significance of using PPIs with caution and ongoing research to better understand the implications of these medications on cardiovascular health.
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spelling pubmed-106099862023-10-28 Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population? Tayal, Rohit Yasmin, Sabina Chauhan, Samrat Singh, Thakur Gurjeet Saini, Monika Shorog, Eman Althubyani, Maryam M. Alsaadi, Baiaan H. Aljohani, Fatimah Alenazi, Maram A. Abutaily, Sarah A. Ansari, Mohammad Yousuf Pharmaceuticals (Basel) Review Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the development of other serious health problems, it can have detrimental consequences for patients. This article explores the correlation between persistent proton pump inhibitor (PPI) use and hypertension, a common cardiovascular ailment. While PPIs are beneficial in treating various gastrointestinal problems, their availability without a prescription has resulted in self-medication and long-term use without medical monitoring. Recent findings have revealed a link between long-term PPI usage and increased cardiovascular risks, particularly hypertension. This study investigates the intricate mechanisms underlying PPI’s effects, focusing on potential pathways contributing to hypertension, such as endothelial dysfunction, disruption of nitric oxide bioavailability, vitamin B deficiency, hypocalcemia, and hypomagnesemia. The discussion explains how long-term PPI use can disrupt normal endothelial function, vascular control, and mineral balance, eventually leading to hypertension. The article emphasizes the significance of using PPIs with caution and ongoing research to better understand the implications of these medications on cardiovascular health. MDPI 2023-09-30 /pmc/articles/PMC10609986/ /pubmed/37895858 http://dx.doi.org/10.3390/ph16101387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tayal, Rohit
Yasmin, Sabina
Chauhan, Samrat
Singh, Thakur Gurjeet
Saini, Monika
Shorog, Eman
Althubyani, Maryam M.
Alsaadi, Baiaan H.
Aljohani, Fatimah
Alenazi, Maram A.
Abutaily, Sarah A.
Ansari, Mohammad Yousuf
Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title_full Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title_fullStr Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title_full_unstemmed Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title_short Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
title_sort are proton pump inhibitors contributing in emerging new hypertensive population?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609986/
https://www.ncbi.nlm.nih.gov/pubmed/37895858
http://dx.doi.org/10.3390/ph16101387
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