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Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study
The formation of a dense fibrous capsule around the foreign body and its contracture is the most common complication of biomaterial implantation. The aim of our research is to find out how the surface of the implant influences the inflammatory and fibrotic reactions in the surrounding tissues. We ma...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610271/ https://www.ncbi.nlm.nih.gov/pubmed/37896364 http://dx.doi.org/10.3390/polym15204119 |
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author | Ivanova, Elena Fayzullin, Alexey Minaev, Nikita Dolganova, Irina Serejnikova, Natalia Gafarova, Elvira Tokarev, Mark Minaeva, Ekaterina Aleksandrova, Polina Reshetov, Igor Timashev, Peter Shekhter, Anatoly |
author_facet | Ivanova, Elena Fayzullin, Alexey Minaev, Nikita Dolganova, Irina Serejnikova, Natalia Gafarova, Elvira Tokarev, Mark Minaeva, Ekaterina Aleksandrova, Polina Reshetov, Igor Timashev, Peter Shekhter, Anatoly |
author_sort | Ivanova, Elena |
collection | PubMed |
description | The formation of a dense fibrous capsule around the foreign body and its contracture is the most common complication of biomaterial implantation. The aim of our research is to find out how the surface of the implant influences the inflammatory and fibrotic reactions in the surrounding tissues. We made three types of implants with a remote surface topography formed of polylactide granules with different diameters: large (100–200 µm), medium (56–100 µm) and small (1–56 µm). We placed these implants in skin pockets in the ears of six chinchilla rabbits. We explanted the implants on the 7th, 14th, 30th and 60th days and performed optical coherence tomography, and histological, immunohistochemical and morphometric studies. We examined 72 samples and compared the composition of immune cell infiltration, vascularization, the thickness of the peri-implant tissues, the severity of fibrotic processes and α-SMA expression in myofibroblasts. We analyzed the scattering coefficient of tissue layers on OCT scans. We found that implants made from large granules induced a milder inflammatory process and slower formation of a connective tissue capsule around the foreign body. Our results prove the importance of assessing the surface texture in order to avoid the formation of capsular contracture after implantation. |
format | Online Article Text |
id | pubmed-10610271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106102712023-10-28 Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study Ivanova, Elena Fayzullin, Alexey Minaev, Nikita Dolganova, Irina Serejnikova, Natalia Gafarova, Elvira Tokarev, Mark Minaeva, Ekaterina Aleksandrova, Polina Reshetov, Igor Timashev, Peter Shekhter, Anatoly Polymers (Basel) Article The formation of a dense fibrous capsule around the foreign body and its contracture is the most common complication of biomaterial implantation. The aim of our research is to find out how the surface of the implant influences the inflammatory and fibrotic reactions in the surrounding tissues. We made three types of implants with a remote surface topography formed of polylactide granules with different diameters: large (100–200 µm), medium (56–100 µm) and small (1–56 µm). We placed these implants in skin pockets in the ears of six chinchilla rabbits. We explanted the implants on the 7th, 14th, 30th and 60th days and performed optical coherence tomography, and histological, immunohistochemical and morphometric studies. We examined 72 samples and compared the composition of immune cell infiltration, vascularization, the thickness of the peri-implant tissues, the severity of fibrotic processes and α-SMA expression in myofibroblasts. We analyzed the scattering coefficient of tissue layers on OCT scans. We found that implants made from large granules induced a milder inflammatory process and slower formation of a connective tissue capsule around the foreign body. Our results prove the importance of assessing the surface texture in order to avoid the formation of capsular contracture after implantation. MDPI 2023-10-17 /pmc/articles/PMC10610271/ /pubmed/37896364 http://dx.doi.org/10.3390/polym15204119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ivanova, Elena Fayzullin, Alexey Minaev, Nikita Dolganova, Irina Serejnikova, Natalia Gafarova, Elvira Tokarev, Mark Minaeva, Ekaterina Aleksandrova, Polina Reshetov, Igor Timashev, Peter Shekhter, Anatoly Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title | Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title_full | Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title_fullStr | Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title_full_unstemmed | Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title_short | Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study |
title_sort | surface topography of pla implants defines the outcome of foreign body reaction: an in vivo study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610271/ https://www.ncbi.nlm.nih.gov/pubmed/37896364 http://dx.doi.org/10.3390/polym15204119 |
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