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Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We perform...

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Autores principales: Yiu, Ching-Yi, Liu, Chien-Cheng, Wu, Jheng-Yan, Tsai, Wen-Wen, Liu, Ping-Hsin, Cheng, Wan-Jung, Chen, Jen-Yin, Hung, Kuo-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610298/
https://www.ncbi.nlm.nih.gov/pubmed/37892423
http://dx.doi.org/10.3390/nu15204348
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author Yiu, Ching-Yi
Liu, Chien-Cheng
Wu, Jheng-Yan
Tsai, Wen-Wen
Liu, Ping-Hsin
Cheng, Wan-Jung
Chen, Jen-Yin
Hung, Kuo-Chuan
author_facet Yiu, Ching-Yi
Liu, Chien-Cheng
Wu, Jheng-Yan
Tsai, Wen-Wen
Liu, Ping-Hsin
Cheng, Wan-Jung
Chen, Jen-Yin
Hung, Kuo-Chuan
author_sort Yiu, Ching-Yi
collection PubMed
description Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We performed a systematic review and meta-analysis to clarify this relationship. Databases were searched for studies examining the association between pretreatment GNRI and overall survival in patients with HNC. Ten studies with 2793 patients were included. Meta-analysis demonstrated that low GNRI was associated with significantly worse overall survival compared to high GNRI (hazard ratio [HR]:2.84, 95% CI 2.07–3.91, p < 0.00001). Older age (HR:1.73; 95% CI, 1.35–2.22; p < 0.0001), male sex (HR:1.7; 95% CI, 1.12–2.6; p = 0.01), advanced tumor stage (HR: 2.5; 95% CI, 1.72–3.63; p < 0.00001), and higher T-/N-stage (HR = 1.69 and 1.98, respectively) were also predictive of unfavorable outcomes. The GNRI had the highest HR, suggesting potent predictive ability. Despite limitations, including retrospective design and potential publication bias, our study indicates that low pretreatment GNRI predicts poor overall survival in patients with HNC. The GNRI is an inexpensive, routinely available biomarker that could improve prognostication and guide management decisions. Additional research is warranted to validate these findings.
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spelling pubmed-106102982023-10-28 Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis Yiu, Ching-Yi Liu, Chien-Cheng Wu, Jheng-Yan Tsai, Wen-Wen Liu, Ping-Hsin Cheng, Wan-Jung Chen, Jen-Yin Hung, Kuo-Chuan Nutrients Review Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We performed a systematic review and meta-analysis to clarify this relationship. Databases were searched for studies examining the association between pretreatment GNRI and overall survival in patients with HNC. Ten studies with 2793 patients were included. Meta-analysis demonstrated that low GNRI was associated with significantly worse overall survival compared to high GNRI (hazard ratio [HR]:2.84, 95% CI 2.07–3.91, p < 0.00001). Older age (HR:1.73; 95% CI, 1.35–2.22; p < 0.0001), male sex (HR:1.7; 95% CI, 1.12–2.6; p = 0.01), advanced tumor stage (HR: 2.5; 95% CI, 1.72–3.63; p < 0.00001), and higher T-/N-stage (HR = 1.69 and 1.98, respectively) were also predictive of unfavorable outcomes. The GNRI had the highest HR, suggesting potent predictive ability. Despite limitations, including retrospective design and potential publication bias, our study indicates that low pretreatment GNRI predicts poor overall survival in patients with HNC. The GNRI is an inexpensive, routinely available biomarker that could improve prognostication and guide management decisions. Additional research is warranted to validate these findings. MDPI 2023-10-12 /pmc/articles/PMC10610298/ /pubmed/37892423 http://dx.doi.org/10.3390/nu15204348 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yiu, Ching-Yi
Liu, Chien-Cheng
Wu, Jheng-Yan
Tsai, Wen-Wen
Liu, Ping-Hsin
Cheng, Wan-Jung
Chen, Jen-Yin
Hung, Kuo-Chuan
Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title_full Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title_fullStr Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title_full_unstemmed Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title_short Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis
title_sort efficacy of the geriatric nutritional risk index for predicting overall survival in patients with head and neck cancer: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610298/
https://www.ncbi.nlm.nih.gov/pubmed/37892423
http://dx.doi.org/10.3390/nu15204348
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