LipL41 and LigA/LigB Gene Silencing on a LipL32 Knockout Leptospira interrogans Reveals the Impact of Multiple Mutations on Virulence

Leptospirosis is a global zoonosis caused by pathogenic bacteria of the genus Leptospira. The application of the CRISPR/Cas9 system has facilitated the generation of mutants and subsequent evaluation of phenotypes. Since DNA breaks induced by RNA-guided Cas9 nuclease are lethal to Leptospira, differ...

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Detalles Bibliográficos
Autores principales: Fernandes, Luis Guilherme V., Foltran, Bruno B., Teixeira, Aline F., Nascimento, Ana Lucia Tabet Oller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610384/
https://www.ncbi.nlm.nih.gov/pubmed/37887707
http://dx.doi.org/10.3390/pathogens12101191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610384/
https://www.ncbi.nlm.nih.gov/pubmed/37887707
http://dx.doi.org/10.3390/pathogens12101191

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