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Role of Resolvins in Inflammatory and Neuropathic Pain

Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease i...

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Autores principales: Park, Jaeik, Roh, Jueun, Pan, Jingying, Kim, Yong Ho, Park, Chul-Kyu, Jo, Youn Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610411/
https://www.ncbi.nlm.nih.gov/pubmed/37895837
http://dx.doi.org/10.3390/ph16101366
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author Park, Jaeik
Roh, Jueun
Pan, Jingying
Kim, Yong Ho
Park, Chul-Kyu
Jo, Youn Yi
author_facet Park, Jaeik
Roh, Jueun
Pan, Jingying
Kim, Yong Ho
Park, Chul-Kyu
Jo, Youn Yi
author_sort Park, Jaeik
collection PubMed
description Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease in itself. However, inflammation plays a considerable role in the progression of both types of pain. Resolvins, derived from omega-3 fatty acids, actively suppress pro-inflammatory mediators and aid in the resolution of inflammation. Resolvins alleviate various inflammatory and neuropathic pain models by reducing hypersensitivity and regulating inflammatory cytokines and glial activation in the spinal cord and dorsal root ganglia. Thus, resolvins are a promising alternative for pain management with the potential to reduce the side effects associated with conventional medications. Continued research is crucial to unlock the therapeutic potential of resolvins and integrate them into effective clinical pain management strategies. This review aimed to evaluate the literature surrounding the resolvins in inflammatory and neuropathic pain.
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spelling pubmed-106104112023-10-28 Role of Resolvins in Inflammatory and Neuropathic Pain Park, Jaeik Roh, Jueun Pan, Jingying Kim, Yong Ho Park, Chul-Kyu Jo, Youn Yi Pharmaceuticals (Basel) Review Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease in itself. However, inflammation plays a considerable role in the progression of both types of pain. Resolvins, derived from omega-3 fatty acids, actively suppress pro-inflammatory mediators and aid in the resolution of inflammation. Resolvins alleviate various inflammatory and neuropathic pain models by reducing hypersensitivity and regulating inflammatory cytokines and glial activation in the spinal cord and dorsal root ganglia. Thus, resolvins are a promising alternative for pain management with the potential to reduce the side effects associated with conventional medications. Continued research is crucial to unlock the therapeutic potential of resolvins and integrate them into effective clinical pain management strategies. This review aimed to evaluate the literature surrounding the resolvins in inflammatory and neuropathic pain. MDPI 2023-09-27 /pmc/articles/PMC10610411/ /pubmed/37895837 http://dx.doi.org/10.3390/ph16101366 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Jaeik
Roh, Jueun
Pan, Jingying
Kim, Yong Ho
Park, Chul-Kyu
Jo, Youn Yi
Role of Resolvins in Inflammatory and Neuropathic Pain
title Role of Resolvins in Inflammatory and Neuropathic Pain
title_full Role of Resolvins in Inflammatory and Neuropathic Pain
title_fullStr Role of Resolvins in Inflammatory and Neuropathic Pain
title_full_unstemmed Role of Resolvins in Inflammatory and Neuropathic Pain
title_short Role of Resolvins in Inflammatory and Neuropathic Pain
title_sort role of resolvins in inflammatory and neuropathic pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610411/
https://www.ncbi.nlm.nih.gov/pubmed/37895837
http://dx.doi.org/10.3390/ph16101366
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