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Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely, glutaric, vanillic, 2,6-dihydroxybenzoic, protocat...

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Detalles Bibliográficos
Autores principales:	Yu, Hongmei, Zhang, Li, Liu, Meiju, Yang, Dezhi, He, Guorong, Zhang, Baoxi, Gong, Ningbo, Lu, Yang, Du, Guanhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610424/ https://www.ncbi.nlm.nih.gov/pubmed/37895820 http://dx.doi.org/10.3390/ph16101349

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