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Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application

The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds thr...

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Autores principales: Calienni, Maria Natalia, Martínez, Luis Manuel, Izquierdo, Maria Cecilia, Alonso, Silvia del Valle, Montanari, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610526/
https://www.ncbi.nlm.nih.gov/pubmed/37896152
http://dx.doi.org/10.3390/pharmaceutics15102392
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author Calienni, Maria Natalia
Martínez, Luis Manuel
Izquierdo, Maria Cecilia
Alonso, Silvia del Valle
Montanari, Jorge
author_facet Calienni, Maria Natalia
Martínez, Luis Manuel
Izquierdo, Maria Cecilia
Alonso, Silvia del Valle
Montanari, Jorge
author_sort Calienni, Maria Natalia
collection PubMed
description The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds through the skin, and are applicable in pharmaceuticals and cosmetics. Formulations underwent flow analysis and were fitted to the Herschel–Bulkley model due to their prevalent non-Newtonian behavior in most cases. Linear viscoelastic regions (LVR) were identified, and G′ and G″ moduli were determined via frequency sweep steps, considering the impact of temperature and aging. The formulations exhibited non-Newtonian behavior with pseudoplastic traits in most cases, with UDL incorporation inducing rheological changes. LVR and frequency sweep tests indicated predominantly elastic solid behavior, with G′ higher than G″, at different temperatures and post-production times. Tan δ values also illustrated a predominant solid-like behavior over liquid. This study provides pivotal insights into the rheological and viscoelastic features of topical formulations, emphasizing the crucial role of meticulous vehicle and formulation selection when incorporating UDL or analogous liposomal drug delivery systems.
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spelling pubmed-106105262023-10-28 Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application Calienni, Maria Natalia Martínez, Luis Manuel Izquierdo, Maria Cecilia Alonso, Silvia del Valle Montanari, Jorge Pharmaceutics Article The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds through the skin, and are applicable in pharmaceuticals and cosmetics. Formulations underwent flow analysis and were fitted to the Herschel–Bulkley model due to their prevalent non-Newtonian behavior in most cases. Linear viscoelastic regions (LVR) were identified, and G′ and G″ moduli were determined via frequency sweep steps, considering the impact of temperature and aging. The formulations exhibited non-Newtonian behavior with pseudoplastic traits in most cases, with UDL incorporation inducing rheological changes. LVR and frequency sweep tests indicated predominantly elastic solid behavior, with G′ higher than G″, at different temperatures and post-production times. Tan δ values also illustrated a predominant solid-like behavior over liquid. This study provides pivotal insights into the rheological and viscoelastic features of topical formulations, emphasizing the crucial role of meticulous vehicle and formulation selection when incorporating UDL or analogous liposomal drug delivery systems. MDPI 2023-09-27 /pmc/articles/PMC10610526/ /pubmed/37896152 http://dx.doi.org/10.3390/pharmaceutics15102392 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calienni, Maria Natalia
Martínez, Luis Manuel
Izquierdo, Maria Cecilia
Alonso, Silvia del Valle
Montanari, Jorge
Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title_full Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title_fullStr Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title_full_unstemmed Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title_short Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
title_sort rheological and viscoelastic analysis of hybrid formulations for topical application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610526/
https://www.ncbi.nlm.nih.gov/pubmed/37896152
http://dx.doi.org/10.3390/pharmaceutics15102392
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