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Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease
The global health emergency caused by COVID-19 concluded in May 2023, marking the beginning of an endemic phase. This study aimed to evaluate the association between vaccination status and other patient characteristics and the risk of severe disease during this new endemic period. A nationwide cohor...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610663/ https://www.ncbi.nlm.nih.gov/pubmed/37896916 http://dx.doi.org/10.3390/vaccines11101512 |
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author | Mendoza-Cano, Oliver Trujillo, Xóchitl Ríos-Silva, Mónica Lugo-Radillo, Agustin Benites-Godínez, Verónica Bricio-Barrios, Jaime Alberto Cuevas-Arellano, Herguin Benjamin Ríos-Bracamontes, Eder Fernando Serrano-Moreno, Walter Cárdenas, Yolitzy Murillo-Zamora, Efrén |
author_facet | Mendoza-Cano, Oliver Trujillo, Xóchitl Ríos-Silva, Mónica Lugo-Radillo, Agustin Benites-Godínez, Verónica Bricio-Barrios, Jaime Alberto Cuevas-Arellano, Herguin Benjamin Ríos-Bracamontes, Eder Fernando Serrano-Moreno, Walter Cárdenas, Yolitzy Murillo-Zamora, Efrén |
author_sort | Mendoza-Cano, Oliver |
collection | PubMed |
description | The global health emergency caused by COVID-19 concluded in May 2023, marking the beginning of an endemic phase. This study aimed to evaluate the association between vaccination status and other patient characteristics and the risk of severe disease during this new endemic period. A nationwide cohort study was conducted in Mexico, where we analyzed data from 646 adults who had received positive confirmation of COVID-19 through PCR testing from May to August 2023. The overall risk of severe symptoms in the study sample was 5.3%. The average time elapsed from the last vaccine shot to symptom onset was over six months in all the immunized groups (1, 2 or 3 vaccine doses). Compared to unvaccinated patients, those with three vaccine doses showed an elevated risk of severe symptoms. Advancing age and various chronic comorbidities (specifically cardiovascular, kidney, and obstructive pulmonary conditions) were associated with a heightened risk of severe COVID-19 manifestations. These findings underscore the ongoing seriousness of COVID-19, even in an endemic phase, underscoring the urgent need for tailored interventions aimed at high-risk patients. |
format | Online Article Text |
id | pubmed-10610663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106106632023-10-28 Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease Mendoza-Cano, Oliver Trujillo, Xóchitl Ríos-Silva, Mónica Lugo-Radillo, Agustin Benites-Godínez, Verónica Bricio-Barrios, Jaime Alberto Cuevas-Arellano, Herguin Benjamin Ríos-Bracamontes, Eder Fernando Serrano-Moreno, Walter Cárdenas, Yolitzy Murillo-Zamora, Efrén Vaccines (Basel) Communication The global health emergency caused by COVID-19 concluded in May 2023, marking the beginning of an endemic phase. This study aimed to evaluate the association between vaccination status and other patient characteristics and the risk of severe disease during this new endemic period. A nationwide cohort study was conducted in Mexico, where we analyzed data from 646 adults who had received positive confirmation of COVID-19 through PCR testing from May to August 2023. The overall risk of severe symptoms in the study sample was 5.3%. The average time elapsed from the last vaccine shot to symptom onset was over six months in all the immunized groups (1, 2 or 3 vaccine doses). Compared to unvaccinated patients, those with three vaccine doses showed an elevated risk of severe symptoms. Advancing age and various chronic comorbidities (specifically cardiovascular, kidney, and obstructive pulmonary conditions) were associated with a heightened risk of severe COVID-19 manifestations. These findings underscore the ongoing seriousness of COVID-19, even in an endemic phase, underscoring the urgent need for tailored interventions aimed at high-risk patients. MDPI 2023-09-22 /pmc/articles/PMC10610663/ /pubmed/37896916 http://dx.doi.org/10.3390/vaccines11101512 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Mendoza-Cano, Oliver Trujillo, Xóchitl Ríos-Silva, Mónica Lugo-Radillo, Agustin Benites-Godínez, Verónica Bricio-Barrios, Jaime Alberto Cuevas-Arellano, Herguin Benjamin Ríos-Bracamontes, Eder Fernando Serrano-Moreno, Walter Cárdenas, Yolitzy Murillo-Zamora, Efrén Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title | Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title_full | Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title_fullStr | Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title_full_unstemmed | Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title_short | Association between Vaccination Status for COVID-19 and the Risk of Severe Symptoms during the Endemic Phase of the Disease |
title_sort | association between vaccination status for covid-19 and the risk of severe symptoms during the endemic phase of the disease |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610663/ https://www.ncbi.nlm.nih.gov/pubmed/37896916 http://dx.doi.org/10.3390/vaccines11101512 |
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