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Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges
Dogs with visceral leishmaniasis play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the o...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610753/ https://www.ncbi.nlm.nih.gov/pubmed/37896969 http://dx.doi.org/10.3390/vaccines11101565 |
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author | Leite, Jaqueline Costa Gonçalves, Ana Alice Maia de Oliveira, Diana Souza Resende, Lucilene Aparecida Boas, Diego Fernandes Vilas Ribeiro, Helen Silva Pereira, Diogo Fonseca Soares da Silva, Augusto Ventura Mariano, Reysla Maria da Silveira Reis, Pedro Campos Carvalhaes Nakasone, Eiji Nakasone França-Silva, João Carlos Galdino, Alexsandro Sobreira Paes, Paulo Ricardo de Oliveira Melo, Marília Martins Dias, Edelberto Santos Chávez-Fumagalli, Miguel Angel da Silveira-Lemos, Denise Dutra, Walderez Ornelas Giunchetti, Rodolfo Cordeiro |
author_facet | Leite, Jaqueline Costa Gonçalves, Ana Alice Maia de Oliveira, Diana Souza Resende, Lucilene Aparecida Boas, Diego Fernandes Vilas Ribeiro, Helen Silva Pereira, Diogo Fonseca Soares da Silva, Augusto Ventura Mariano, Reysla Maria da Silveira Reis, Pedro Campos Carvalhaes Nakasone, Eiji Nakasone França-Silva, João Carlos Galdino, Alexsandro Sobreira Paes, Paulo Ricardo de Oliveira Melo, Marília Martins Dias, Edelberto Santos Chávez-Fumagalli, Miguel Angel da Silveira-Lemos, Denise Dutra, Walderez Ornelas Giunchetti, Rodolfo Cordeiro |
author_sort | Leite, Jaqueline Costa |
collection | PubMed |
description | Dogs with visceral leishmaniasis play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec(®) and LetiFend(®), have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies, such as the development of a transmission-blocking vaccines (TBVs) already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBV studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results, thus justifying the further development of this approach. |
format | Online Article Text |
id | pubmed-10610753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106107532023-10-28 Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges Leite, Jaqueline Costa Gonçalves, Ana Alice Maia de Oliveira, Diana Souza Resende, Lucilene Aparecida Boas, Diego Fernandes Vilas Ribeiro, Helen Silva Pereira, Diogo Fonseca Soares da Silva, Augusto Ventura Mariano, Reysla Maria da Silveira Reis, Pedro Campos Carvalhaes Nakasone, Eiji Nakasone França-Silva, João Carlos Galdino, Alexsandro Sobreira Paes, Paulo Ricardo de Oliveira Melo, Marília Martins Dias, Edelberto Santos Chávez-Fumagalli, Miguel Angel da Silveira-Lemos, Denise Dutra, Walderez Ornelas Giunchetti, Rodolfo Cordeiro Vaccines (Basel) Review Dogs with visceral leishmaniasis play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec(®) and LetiFend(®), have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies, such as the development of a transmission-blocking vaccines (TBVs) already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBV studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results, thus justifying the further development of this approach. MDPI 2023-10-05 /pmc/articles/PMC10610753/ /pubmed/37896969 http://dx.doi.org/10.3390/vaccines11101565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leite, Jaqueline Costa Gonçalves, Ana Alice Maia de Oliveira, Diana Souza Resende, Lucilene Aparecida Boas, Diego Fernandes Vilas Ribeiro, Helen Silva Pereira, Diogo Fonseca Soares da Silva, Augusto Ventura Mariano, Reysla Maria da Silveira Reis, Pedro Campos Carvalhaes Nakasone, Eiji Nakasone França-Silva, João Carlos Galdino, Alexsandro Sobreira Paes, Paulo Ricardo de Oliveira Melo, Marília Martins Dias, Edelberto Santos Chávez-Fumagalli, Miguel Angel da Silveira-Lemos, Denise Dutra, Walderez Ornelas Giunchetti, Rodolfo Cordeiro Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title_full | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title_fullStr | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title_full_unstemmed | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title_short | Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges |
title_sort | transmission-blocking vaccines for canine visceral leishmaniasis: new progress and yet new challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610753/ https://www.ncbi.nlm.nih.gov/pubmed/37896969 http://dx.doi.org/10.3390/vaccines11101565 |
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