Development of Chitosan/Sodium Carboxymethylcellulose Complexes to Improve the Simvastatin Release Rate: Polymer/Polymer and Drug/Polymer Interactions’ Effects on Kinetic Models

Simvastatin (SIM) is a potent lipid-lowering drug used to control hyper-cholesterolemia and prevent cardiovascular diseases. SIM presents low oral bioavailability (5%) because of its low aqueous solubility. In this work, polyelectrolyte complexes (PEC) are developed with different chitosan (CS) and...

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Detalles Bibliográficos
Autores principales: López-Manzanara Pérez, Celia, Torres-Pabón, Norma Sofía, Laguna, Almudena, Torrado, Guillermo, de la Torre-Iglesias, Paloma M., Torrado-Santiago, Santiago, Torrado-Salmerón, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610795/
https://www.ncbi.nlm.nih.gov/pubmed/37896428
http://dx.doi.org/10.3390/polym15204184

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