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Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application

In recent years, the administration of fentanyl (FNTL) implicitly in transdermal drug delivery systems (TDDS) has vastly increased in chronic pain treatment. Non-medical and uncontrolled use of FNTL in TFDS (transdermal fentanyl delivery systems) may reveal toxic effects by the route of exposure, de...

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Autores principales: Sommerfeld-Klatta, Karina, Jiers, Wiktoria, Łukasik-Głębocka, Magdalena, Tezyk, Artur, Dolińska-Kaczmarek, Klaudia, Walter, Kamil, Świderski, Paweł, Rzepczyk, Szymon, Zielińska-Psuja, Barbara, Żaba, Czesław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610823/
https://www.ncbi.nlm.nih.gov/pubmed/37888722
http://dx.doi.org/10.3390/toxics11100872
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author Sommerfeld-Klatta, Karina
Jiers, Wiktoria
Łukasik-Głębocka, Magdalena
Tezyk, Artur
Dolińska-Kaczmarek, Klaudia
Walter, Kamil
Świderski, Paweł
Rzepczyk, Szymon
Zielińska-Psuja, Barbara
Żaba, Czesław
author_facet Sommerfeld-Klatta, Karina
Jiers, Wiktoria
Łukasik-Głębocka, Magdalena
Tezyk, Artur
Dolińska-Kaczmarek, Klaudia
Walter, Kamil
Świderski, Paweł
Rzepczyk, Szymon
Zielińska-Psuja, Barbara
Żaba, Czesław
author_sort Sommerfeld-Klatta, Karina
collection PubMed
description In recent years, the administration of fentanyl (FNTL) implicitly in transdermal drug delivery systems (TDDS) has vastly increased in chronic pain treatment. Non-medical and uncontrolled use of FNTL in TFDS (transdermal fentanyl delivery systems) may reveal toxic effects by the route of exposure, dermal or alternative, by ingestion of patches, and drug release in the stomach. The purpose of this study was to present three different cases of FNTL poisonings, two of which resulted in death due to TFDS abuse. The first case is a 66-year-old woman treated for accidental FTNL poisoning resulting in acute respiratory distress syndrome. Two remaining cases are a 31-year-old woman and a 25-year-old man who died as a result of FNTL overdose after on-skin and ingestion application of the drug patches. During the hospitalization of the 66-year-old patient, in blood samples, FNTL was confirmed at a concentration of 10.0 ng/mL. Tests run on blood taken from the corpses of 25- and 31-year-old patients exhibited FNTL presence in concentrations of 29.1 ng/mL and 38.7 ng/mL, respectively. The various routes of administration and ultimately toxic effects are important to present because, in TDDS, fentanyl can be a reason for severe to fatal poisoning, as shown by the three cases above.
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spelling pubmed-106108232023-10-28 Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application Sommerfeld-Klatta, Karina Jiers, Wiktoria Łukasik-Głębocka, Magdalena Tezyk, Artur Dolińska-Kaczmarek, Klaudia Walter, Kamil Świderski, Paweł Rzepczyk, Szymon Zielińska-Psuja, Barbara Żaba, Czesław Toxics Case Report In recent years, the administration of fentanyl (FNTL) implicitly in transdermal drug delivery systems (TDDS) has vastly increased in chronic pain treatment. Non-medical and uncontrolled use of FNTL in TFDS (transdermal fentanyl delivery systems) may reveal toxic effects by the route of exposure, dermal or alternative, by ingestion of patches, and drug release in the stomach. The purpose of this study was to present three different cases of FNTL poisonings, two of which resulted in death due to TFDS abuse. The first case is a 66-year-old woman treated for accidental FTNL poisoning resulting in acute respiratory distress syndrome. Two remaining cases are a 31-year-old woman and a 25-year-old man who died as a result of FNTL overdose after on-skin and ingestion application of the drug patches. During the hospitalization of the 66-year-old patient, in blood samples, FNTL was confirmed at a concentration of 10.0 ng/mL. Tests run on blood taken from the corpses of 25- and 31-year-old patients exhibited FNTL presence in concentrations of 29.1 ng/mL and 38.7 ng/mL, respectively. The various routes of administration and ultimately toxic effects are important to present because, in TDDS, fentanyl can be a reason for severe to fatal poisoning, as shown by the three cases above. MDPI 2023-10-20 /pmc/articles/PMC10610823/ /pubmed/37888722 http://dx.doi.org/10.3390/toxics11100872 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Sommerfeld-Klatta, Karina
Jiers, Wiktoria
Łukasik-Głębocka, Magdalena
Tezyk, Artur
Dolińska-Kaczmarek, Klaudia
Walter, Kamil
Świderski, Paweł
Rzepczyk, Szymon
Zielińska-Psuja, Barbara
Żaba, Czesław
Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title_full Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title_fullStr Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title_full_unstemmed Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title_short Severe and Fatal Fentanyl Poisonings from Transdermal Systems after On-Skin and Ingestion Application
title_sort severe and fatal fentanyl poisonings from transdermal systems after on-skin and ingestion application
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610823/
https://www.ncbi.nlm.nih.gov/pubmed/37888722
http://dx.doi.org/10.3390/toxics11100872
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