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Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17

Bone morphogenic protein (BMP) signaling is critical for intestinal development, homeostasis, and function performance. Although the function of BMP signaling in the intestinal epithelium is well appreciated, the direct effect of BMP on intestinal stromal cells is poorly understood. Here, we show th...

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Autores principales: Wang, Yalong, Lou, Ruoyu, Zhang, Zhe, Xiao, Chuyu, Yu, Shicheng, Wei, Siting, Liu, Yuan, Fu, Wei, Li, Baojie, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610902/
https://www.ncbi.nlm.nih.gov/pubmed/37889976
http://dx.doi.org/10.1126/sciadv.adi1827
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author Wang, Yalong
Lou, Ruoyu
Zhang, Zhe
Xiao, Chuyu
Yu, Shicheng
Wei, Siting
Liu, Yuan
Fu, Wei
Li, Baojie
Chen, Ye-Guang
author_facet Wang, Yalong
Lou, Ruoyu
Zhang, Zhe
Xiao, Chuyu
Yu, Shicheng
Wei, Siting
Liu, Yuan
Fu, Wei
Li, Baojie
Chen, Ye-Guang
author_sort Wang, Yalong
collection PubMed
description Bone morphogenic protein (BMP) signaling is critical for intestinal development, homeostasis, and function performance. Although the function of BMP signaling in the intestinal epithelium is well appreciated, the direct effect of BMP on intestinal stromal cells is poorly understood. Here, we show that disruption of BMP signaling by genetic ablation of Alk3 or Smad4 expands the stromal cell pool, the mucosa tumefaction, and colonic polyposis in the large intestine. Interleukin (IL) secretion by stromal cells is notably increased, including IL-1, IL-11, and IL-17. Specifically, IL-1 and IL-17a hyperactivate the mucin production by goblet cells through nuclear factor κB signaling, and abnormal mucin accumulation results in the morphological changes, epithelial barrier destruction, and polyposis development. Together, our results provide an insight into the role of BMP signaling in intestinal stromal cells to regulate epithelium function. This study further highlights the role of mucin-producing goblet cells in intestinal homeostasis and colitis development.
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spelling pubmed-106109022023-10-28 Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17 Wang, Yalong Lou, Ruoyu Zhang, Zhe Xiao, Chuyu Yu, Shicheng Wei, Siting Liu, Yuan Fu, Wei Li, Baojie Chen, Ye-Guang Sci Adv Biomedicine and Life Sciences Bone morphogenic protein (BMP) signaling is critical for intestinal development, homeostasis, and function performance. Although the function of BMP signaling in the intestinal epithelium is well appreciated, the direct effect of BMP on intestinal stromal cells is poorly understood. Here, we show that disruption of BMP signaling by genetic ablation of Alk3 or Smad4 expands the stromal cell pool, the mucosa tumefaction, and colonic polyposis in the large intestine. Interleukin (IL) secretion by stromal cells is notably increased, including IL-1, IL-11, and IL-17. Specifically, IL-1 and IL-17a hyperactivate the mucin production by goblet cells through nuclear factor κB signaling, and abnormal mucin accumulation results in the morphological changes, epithelial barrier destruction, and polyposis development. Together, our results provide an insight into the role of BMP signaling in intestinal stromal cells to regulate epithelium function. This study further highlights the role of mucin-producing goblet cells in intestinal homeostasis and colitis development. American Association for the Advancement of Science 2023-10-27 /pmc/articles/PMC10610902/ /pubmed/37889976 http://dx.doi.org/10.1126/sciadv.adi1827 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Wang, Yalong
Lou, Ruoyu
Zhang, Zhe
Xiao, Chuyu
Yu, Shicheng
Wei, Siting
Liu, Yuan
Fu, Wei
Li, Baojie
Chen, Ye-Guang
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title_full Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title_fullStr Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title_full_unstemmed Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title_short Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
title_sort stromal bmp signaling regulates mucin production in the large intestine via interleukin-1/17
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610902/
https://www.ncbi.nlm.nih.gov/pubmed/37889976
http://dx.doi.org/10.1126/sciadv.adi1827
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