Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation

α-Synuclein (aSyn) aggregation underlies neurodegenerative synucleinopathies. aSyn seeds are proposed to replicate and propagate neuronal pathology like prions. Seeding of aSyn can be recapitulated in cellular systems of aSyn aggregation; however, the mechanism of aSyn seeding and its regulation are...

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Detalles Bibliográficos
Autores principales: Chlebowicz, Julita, Russ, William, Chen, Dailu, Vega, Anthony, Vernino, Steven, White, Charles L., Rizo, Josep, Joachimiak, Lukasz A., Diamond, Marc I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610913/
https://www.ncbi.nlm.nih.gov/pubmed/37889966
http://dx.doi.org/10.1126/sciadv.adh3457

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