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Biocompatible Polymer for Self-Humidification

Lung supportive devices (LSDs) have been extensively utilized in treating patients diagnosed with various respiratory disorders. However, these devices can cause moisture depletion in the upper airway by interfering with the natural lubrication and air conditioning process. To remedy this, current t...

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Detalles Bibliográficos
Autores principales: Al-Jumaily, Ahmed M., Grau-Bartual, Sandra, Weerasinghe, Nimesha T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611040/
https://www.ncbi.nlm.nih.gov/pubmed/37896345
http://dx.doi.org/10.3390/polym15204101
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author Al-Jumaily, Ahmed M.
Grau-Bartual, Sandra
Weerasinghe, Nimesha T.
author_facet Al-Jumaily, Ahmed M.
Grau-Bartual, Sandra
Weerasinghe, Nimesha T.
author_sort Al-Jumaily, Ahmed M.
collection PubMed
description Lung supportive devices (LSDs) have been extensively utilized in treating patients diagnosed with various respiratory disorders. However, these devices can cause moisture depletion in the upper airway by interfering with the natural lubrication and air conditioning process. To remedy this, current technologies implement heated humidification processes, which are bulky, costly, and nonfriendly. However, it has been demonstrated that in a breath cycle, the amount of water vapor in the exhaled air is of a similar quantity to the amount needed to humidify the inhaled air. This research proposes to trap the moisture from exhaled air and reuse it during inhalation by developing a state-of-the-art hydrophilic/hydrophobic polymer tuned to deliver this purpose. Using the atom transfer radical polymerization (ATRP) method, a substrate was successfully created by incorporating poly (N-isopropyl acrylamide) (PNIPAM) onto cotton. The fabricated material exhibited a water vapor release rate of 24.2 ± 1.054%/min at 32 °C, indicating its ability to humidify the inhaled air effectively. These findings highlight the potential of the developed material as a promising solution for applications requiring rapid moisture recovery.
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spelling pubmed-106110402023-10-28 Biocompatible Polymer for Self-Humidification Al-Jumaily, Ahmed M. Grau-Bartual, Sandra Weerasinghe, Nimesha T. Polymers (Basel) Article Lung supportive devices (LSDs) have been extensively utilized in treating patients diagnosed with various respiratory disorders. However, these devices can cause moisture depletion in the upper airway by interfering with the natural lubrication and air conditioning process. To remedy this, current technologies implement heated humidification processes, which are bulky, costly, and nonfriendly. However, it has been demonstrated that in a breath cycle, the amount of water vapor in the exhaled air is of a similar quantity to the amount needed to humidify the inhaled air. This research proposes to trap the moisture from exhaled air and reuse it during inhalation by developing a state-of-the-art hydrophilic/hydrophobic polymer tuned to deliver this purpose. Using the atom transfer radical polymerization (ATRP) method, a substrate was successfully created by incorporating poly (N-isopropyl acrylamide) (PNIPAM) onto cotton. The fabricated material exhibited a water vapor release rate of 24.2 ± 1.054%/min at 32 °C, indicating its ability to humidify the inhaled air effectively. These findings highlight the potential of the developed material as a promising solution for applications requiring rapid moisture recovery. MDPI 2023-10-16 /pmc/articles/PMC10611040/ /pubmed/37896345 http://dx.doi.org/10.3390/polym15204101 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Jumaily, Ahmed M.
Grau-Bartual, Sandra
Weerasinghe, Nimesha T.
Biocompatible Polymer for Self-Humidification
title Biocompatible Polymer for Self-Humidification
title_full Biocompatible Polymer for Self-Humidification
title_fullStr Biocompatible Polymer for Self-Humidification
title_full_unstemmed Biocompatible Polymer for Self-Humidification
title_short Biocompatible Polymer for Self-Humidification
title_sort biocompatible polymer for self-humidification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611040/
https://www.ncbi.nlm.nih.gov/pubmed/37896345
http://dx.doi.org/10.3390/polym15204101
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