Modeling of the Aqueous Solubility of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a] pyrazine-3-carboxamide: From Micronization to Creation of Amorphous–Crystalline Composites with a Polymer

N-butyl-N-methyl-1-phenylpyrrole[1,2-a] pyrazine-3-carboxamide (GML-3) is a potential candidate for combination drug therapy due to its anxiolytic and antidepressant activity. The anxiolytic activity of GML-3 is comparable to diazepam. The antidepressant activity of GML-3 is comparable to amitriptyl...

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Detalles Bibliográficos
Autores principales: Markeev, Vladimir B., Tishkov, Sergey V., Vorobei, Anton M., Parenago, Olga O., Blynskaya, Evgenia V., Alekseev, Konstantin V., Marakhova, Anna I., Vetcher, Alexandre A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611044/
https://www.ncbi.nlm.nih.gov/pubmed/37896380
http://dx.doi.org/10.3390/polym15204136

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