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Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study

Background: Despite the availability of a highly efficacious vaccine, varicella outbreaks are still being reported globally. In this study, we evaluated the real-world effectiveness of varicella vaccination among children between the ages of 1 and 18 years old during the period 2017 to 2019 in Qatar...

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Autores principales: Bibi, Zahra, Nawaz, Ahmed Daniyal, Al Kurbi, Maha, Fakhroo, Shahad, Ferih, Khaled, Al-Jaber, Noor, Alex, Merin, Elawad, Khalid H., Chivese, Tawanda, Zughaier, Susu M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611158/
https://www.ncbi.nlm.nih.gov/pubmed/37896970
http://dx.doi.org/10.3390/vaccines11101567
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author Bibi, Zahra
Nawaz, Ahmed Daniyal
Al Kurbi, Maha
Fakhroo, Shahad
Ferih, Khaled
Al-Jaber, Noor
Alex, Merin
Elawad, Khalid H.
Chivese, Tawanda
Zughaier, Susu M.
author_facet Bibi, Zahra
Nawaz, Ahmed Daniyal
Al Kurbi, Maha
Fakhroo, Shahad
Ferih, Khaled
Al-Jaber, Noor
Alex, Merin
Elawad, Khalid H.
Chivese, Tawanda
Zughaier, Susu M.
author_sort Bibi, Zahra
collection PubMed
description Background: Despite the availability of a highly efficacious vaccine, varicella outbreaks are still being reported globally. In this study, we evaluated the real-world effectiveness of varicella vaccination among children between the ages of 1 and 18 years old during the period 2017 to 2019 in Qatar. Methods: A matched case–control study was conducted that included all reported varicella-infected children who visited the primary healthcare system in Qatar from January 2017 to December 2019. The cases were children under the age of 18 years who were clinically diagnosed with varicella. The controls were of the same age, who visited the Primary Health Care Corporation (PHCC) during 2017–2019 with a skin rash where varicella infection was ruled out. The data on varicella vaccination for each participant were obtained from the electronic database in the PHCC during the study period. Results: We included 862 cases of varicella and 5454 matched controls, with a median age of 8 years (IQR 3–12); 47.4% were female and almost 50% were of Qatari nationality. The year 2019 had the highest varicella infection count with a total of 416 cases. The cases were less likely to be vaccinated against varicella, with approximately a quarter (25.6%) of cases and 36.7% of the controls having either one or two doses of the vaccine (p < 0.001). Compared to not being vaccinated, a single dose vaccination showed a 56% reduction in the odds of varicella infection [OR 0.44, 95% CI: 0.34–0.55; p < 0.000], and a two-dose vaccination showed an 86% reduction in the odds of varicella infection [OR 0.13, 95% CI: 0.06–0.29; p < 0.000]. Conclusion: In this multicultural setting, a two-dose varicella vaccination shows reasonable protection against varicella infection.
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spelling pubmed-106111582023-10-28 Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study Bibi, Zahra Nawaz, Ahmed Daniyal Al Kurbi, Maha Fakhroo, Shahad Ferih, Khaled Al-Jaber, Noor Alex, Merin Elawad, Khalid H. Chivese, Tawanda Zughaier, Susu M. Vaccines (Basel) Article Background: Despite the availability of a highly efficacious vaccine, varicella outbreaks are still being reported globally. In this study, we evaluated the real-world effectiveness of varicella vaccination among children between the ages of 1 and 18 years old during the period 2017 to 2019 in Qatar. Methods: A matched case–control study was conducted that included all reported varicella-infected children who visited the primary healthcare system in Qatar from January 2017 to December 2019. The cases were children under the age of 18 years who were clinically diagnosed with varicella. The controls were of the same age, who visited the Primary Health Care Corporation (PHCC) during 2017–2019 with a skin rash where varicella infection was ruled out. The data on varicella vaccination for each participant were obtained from the electronic database in the PHCC during the study period. Results: We included 862 cases of varicella and 5454 matched controls, with a median age of 8 years (IQR 3–12); 47.4% were female and almost 50% were of Qatari nationality. The year 2019 had the highest varicella infection count with a total of 416 cases. The cases were less likely to be vaccinated against varicella, with approximately a quarter (25.6%) of cases and 36.7% of the controls having either one or two doses of the vaccine (p < 0.001). Compared to not being vaccinated, a single dose vaccination showed a 56% reduction in the odds of varicella infection [OR 0.44, 95% CI: 0.34–0.55; p < 0.000], and a two-dose vaccination showed an 86% reduction in the odds of varicella infection [OR 0.13, 95% CI: 0.06–0.29; p < 0.000]. Conclusion: In this multicultural setting, a two-dose varicella vaccination shows reasonable protection against varicella infection. MDPI 2023-10-05 /pmc/articles/PMC10611158/ /pubmed/37896970 http://dx.doi.org/10.3390/vaccines11101567 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bibi, Zahra
Nawaz, Ahmed Daniyal
Al Kurbi, Maha
Fakhroo, Shahad
Ferih, Khaled
Al-Jaber, Noor
Alex, Merin
Elawad, Khalid H.
Chivese, Tawanda
Zughaier, Susu M.
Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title_full Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title_fullStr Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title_full_unstemmed Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title_short Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
title_sort real-world effectiveness of the varicella vaccine among children and adolescents in qatar: a case–control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611158/
https://www.ncbi.nlm.nih.gov/pubmed/37896970
http://dx.doi.org/10.3390/vaccines11101567
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